My favorite would be Jeb Bush to knock off Bill Nelson in FL. Lincoln Chafee is looking like a Jeffords, both of them ripe for picking in '06.
Jeffords isn't going anywhere - VT is loony-left Land.
Nope. In return for her NOT running for the open Graham seat this time and causing state wide havoc, Katherine Harris was promised a shot at Bill Nelson with 100% party support and access to resources. She won her race for the House this time and will be "seasoned" enough to fill this slot.
Jeb wants to go home to Miami and get back into business (he's a friend of my family from before he was Gov) and he won't seek the Senate. He might still run for Pres in 08, but I doubt it.