Premarin is horses urine....it’s NOT a bio-ID natural hormone....it’s probably good for horses, but not for humans.
Premarin is the same hormone found in humans, and works just as well as the human stuff. At least until fairly recently, there were also hormone products being made from the urine of post-menopausal nuns. But horse urine is cheaper and easier to collect.
I knew a woman who was obsessed with staying young. she took massive amounts of hormones, also stuff from the health food store and rubbed hormone cream into her thighs. Anything anyone told her about she took. She developed a brain disease, I think it is something like Cruczchfelt-Jacobs disease. (I know that is spelled completely wrong) It is to humans what mad cow disease is in cows. She died a horrible death after being slowly incapacitated for several years. I always wondered if something she took to stay young brought it on.