You are wrong there sir, it is not the same as found in humans. My body never made a single drop of horse urine.
He meant the synthetic hormones made from mare urine are used in human hormone replacement therapy.
it’s said to be the equivalent to the hormones produced naturally.
Those horse farms were mare urine is collected from pregnant mares are called PMU farms. It was a profitable business at one time.
Estrone (3-hydroxy-13-methyl- 6,7,8,9,11,12,13,14,15,16- decahydrocyclopenta[a]phenanthren- 17- one) is estrone, whether it’s made in a horse, in a human, or in a lab. That’s the primary form of estrogen found in Premarin. There are smaller amounts of two others, which are not naturally present in humans, but no evidence that they have any harmful effects, and actually quite a bit of research showing that they’re likely to have some beneficial effects (though probably only if taken in larger quantities than the portions found in Premarin).
The problems with Premarin and other common forms of hormone replacement therapy (including “bioidentical” hormones) is that they all involve dosing with a few of the many downstream hormones in the overall web of steroidogenesis. *Some* of these can back-convert to *some* extent, but it’s still a very unnatural disruption of the hormone balance. In the absence of clear genetic abnormalities (e.g. defects in specific enzymes that convert the various steroids into different ones), it makes a lot more sense to supplement steroids that are much further upstream, e.g. pregnenolone and/or DHEA, and let the body choose how much of what to make from these raw materials. That approach is a lot more likely to result in normal, healthy, and properly balanced levels of the large numbers of steroid hormones we naturally have.
Most of the negative health effects that have been traced to hormone replacement therapy are not dependent on whether Premarin vs. products not containing any equine estrogens were used. There’s much stronger evidence that the standard practice of replacing estrogens without simultaneously replacing testosterone (which is upstream from the estrogens) is the key factor in negative health effects. DHEA is upstream from both testosterone and all the human forms of estrogen, and supplementing DHEA therefore does not bypass testosterone production, and flood the body with high levels of estrogen while it is still abnormally low in testosterone.
Even in perfectly healthy people, there is so much individual variation in hormone levels, including day-to-day and intraday variations, that attempts to craft individually customized products that dose many different hormones separately are only slightly more scientifically defensible than the estrogens-only approach. But to the extent that these custom formulations include significant amounts of upstream precursors and/or some of the further downstream androgens, they’re definitely better than taking estrogens only. If there’s any form of estrogen included at all, there’s no evidence to suggest that Premarin wouldn’t be a perfectly good source of that estrogen.