Some peoples bodies are more fussy than others.
What synthetic hormones did you end up on? Or did you just give up on hormone therapy?
My wife went (still is) going through that stage, but the doc refuses to give her hormones to ease her symptoms.
You should get your wifey to a decent doc who will do the lab tests to test ALL her hormones...and then consider the bio-ID compounded ones JUST for her....and have her get tested regularly for the first year.
I stopped taking any hormones completely I feel better if I don’t take anything. I never had much of a problem with hot flashes, sweats and the like, the doctor put me on hormones because it was the thing to do at that time. I am 69 and I have started taking blood pressure medicine and 1/4 gr. aspirin.
That is a good way to put it, my body is very fussy. LOL!