In other words, the dose makes the poison, whether it's fructose or sucrose.
Yes, the dose makes a difference as does exercise & one’s general health. Although in addition to fructose, most fruits also contain varying amount of sucrose, as well as glucose.
So, for example, for those who suffer from fructose malabsorption, some researchers have suggested getting your ‘natural’ sugar from eating fruits that contain equal or less fructose than glucose. For instance, stone fruit, berry fruit or citrus fruit.