When the Israelis were implicated in an assassination scandal that targeted PLO leaders hiding in Europe and ended up with an innocent man getting killed the weapons they used were .22’s and they aimed for multiple shots to the abdomen. I don’t know if it was because they were hoping the leader died an agonizing death or it was considered the best target to aim for. In either case they obviously weren’t worried that the .22 wasn’t going to be powerful enough for the job.
They probably had something other than air in the hollow point too.