funny how this article demonstrates exactly the opposite of what you stated about Vitamin C. #1 it is safe and #2 it works and #3 it is cheap - the nightmare for all the researchers whose income is derived from new drugs that do nothing and often cause harm. Note that in ancient Greece Pharmakon meant either "cure" or "poison"
Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937164/
Alpha A Fowler, III, Aamer A Syed, [...], and Ramesh Natarajan
Background
Parenterally administered ascorbic acid modulates sepsis-induced inflammation and coagulation in experimental animal models. The objective of this randomized, double-blind, placebo-controlled, phase I trial was to determine the safety of intravenously infused ascorbic acid in patients with severe sepsis.
Methods
Twenty-four patients with severe sepsis in the medical intensive care unit were randomized 1:1:1 to receive intravenous infusions every six hours for four days of ascorbic acid: Lo-AscA (50 mg/kg/24 h, n = 8), or Hi-AscA (200 mg/kg/24 h, n = 8), or Placebo (5% dextrose/water, n = 8). The primary end points were ascorbic acid safety and tolerability, assessed as treatment-related adverse-event frequency and severity. Patients were monitored for worsened arterial hypotension, tachycardia, hypernatremia, and nausea or vomiting. In addition Sequential Organ Failure Assessment (SOFA) scores and plasma levels of ascorbic acid, C-reactive protein, procalcitonin, and thrombomodulin were monitored.
Results
Mean plasma ascorbic acid levels at entry for the entire cohort were 17.9 ± 2.4 μM (normal range 50-70 μM). Ascorbic acid infusion rapidly and significantly increased plasma ascorbic acid levels. No adverse safety events were observed in ascorbic acid-infused patients. Patients receiving ascorbic acid exhibited prompt reductions in SOFA scores while placebo patients exhibited no such reduction. Ascorbic acid significantly reduced the proinflammatory biomarkers C-reactive protein and procalcitonin. Unlike placebo patients, thrombomodulin in ascorbic acid infused patients exhibited no significant rise, suggesting attenuation of vascular endothelial injury.
Conclusions
Intravenous ascorbic acid infusion was safe and well tolerated in this study and may positively impact the extent of multiple organ failure and biomarkers of inflammation and endothelial injury.
PS It works on exactly what we were discussing regarding Ebola: Sepsis Multiple organ failure Inflammation Hemorrhage
I’m not interested, why do you feel the need to ping everyone to your posts?
Please take me off your ping list.
Normally I don't even bother to get involved in these "snake oil" arguments. But I told you once already what I think of vitamin C.
Some 40 years ago they were hawking it to cure the common cold and flu..... it failed failed..because the promises and the research was BS
Ten years or so after that they started with the high dose therapies for everything from the flu to cancer and they have been doing it ever since.
Interest continues to be difficult to come by so they have to continually mine the population for new suckers, and you want to know why? Because it's does nothing for those who need something to be done and they continue with the same promises and the same inferences that it's a wonder drug and now they do it as a add on treatment to other drugs which we do know has effect. Might as well claim that saline is a wonder drug and you will still get good results the way they do the research.. All you do with that stuff is pee it right back out and for anyone who's kidneys or liver have been abused by other necessary FDA approved therapy's, it can actually do more harm. The drugs we have been using in this country from anti-biotic's to cancer therapies, to over the counter pain and other OTC meds are all taxing the renal systems of the people who take them, including me. Some are necessary as no other options are available but at 10$ per pound it does not make them more effective or less dangerous.
I would not touch C with a ten foot pole, nor Tylenol, Zocor, or anything that I did not absolutely need that day. It's all snake oil, as far as I am concerned. Take with caution, and that "well tolerated" BS is just that....Bull Shite.. For pain I still use aspirin...It works.. but like anything you have use as necessary and not as a habit. However it is about 10 bucks a pound as well. Like anything else that you eat too much of it will hurt you.
I would never megadose any foreign substance. Nor should you or anyone unless it was the last resort.