Skeeter, that's nothing to worry about.
During his debating career, Cruz doubtless confronted a number of females. By definition, he obviously dealt with them effectively.
Moreover, Cruz has already proved that he is politically aware and nimble. He's not going to do anything that's off key.
Plus he a Latino. I doubt that he’d want to draw that card, but it’s there. Hillary needs to watch her step just as much, if not more, than he does.