Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Immunotherapy, Jimmy Carter's new cancer treatment, explained
Vox ^ | August 21, 2015 | Julia Belluz

Posted on 08/22/2015 9:21:12 AM PDT by Tired of Taxes

At a press conference today, former President Jimmy Carter revealed the ways he is tackling the melanoma cancer that has spread to his brain and liver: He'll receive radiation, as well as another lesser-known treatment called immunotherapy.

Up until now, most cancer patients only had a few options. They could get chemotherapy or radiation that kills cancerous cells and stops them from dividing, or surgery to cut out the disease. Yet the success rate of these options is far from perfect.

Now a new kind of cancer treatment has come into play: immunotherapies. These treatments, which include Carter's infusion called pembrolizumab, try to stimulate the immune system, often through artificial proteins or vaccines, to help the body attack cancer from within.

The positive outcomes for some patients receiving immunotherapy seem extremely impressive. Doctors have seen deadly tumors disappear, and patients who were supposed to die have gone into remission for years. Such prolonged responses to treatment in very sick patients are almost never seen with chemotherapy.

Drug companies are jumping into the fray to bring new immunotherapies to market. As the Wall Street Journal reported, half of Standard & Poor’s top 10 list of promising drugs for 2015 included cancer immunotherapies. In the bleak landscape for cancer treatment, the news is inspiring.

"These latest immunotherapy drugs," Carter said, "whether alone or in combination with other treatments, seem to be the future of cancer therapy."

But is immunotherapy the holy grail scientists have been searching for, or just the latest in a long line of overhyped cancer fixes that flopped? Here's how doctors think about these drugs.

The idea behind immunotherapy is at least a century old

In the 1890s, a New York surgeon named William Coley noted that a patient's cancer seemed to vanish after he came down with a bacterial infection. Coley thought maybe the bacteria had activated his immune system to fight the cancer.

He wasn't alone. Before him, other doctors had also noted the weird link between infections and spontaneous cancer remissions. So Coley started experimenting by injecting people's tumors with bacteria. He found that the cancer regressed in some of those patients.

While Coley is now regarded as the "father of immunotherapy," his peers simply didn't believe his results. The idea of immunotherapy for cancer fell in and out of favor over the next 100 years, particularly as doctors were having success with radiation and chemo.

Immunotherapy can stop cancer — but it occasionally causes serious problems

Flash forward to 1992, when the first immunotherapy for cancer came on the market. Interleukin-2 (IL-2) was approved by the Food and Drug Administration to treat metastatic renal cell carcinoma, an advanced form of kidney cancer, and, a few years later, to treat advanced melanoma (a deadly skin cancer).

When patients took large doses of IL-2 — a protein that's made during an immune response — their bodies sometimes attacked cancer cells, and the drug appeared to save lives. Mark Gorman, the first patient who got the treatment, survived a cancer that should have killed him within months.

But IL-2 treatment hasn't been completely positive. "Despite its potential for miracles, IL-2 produces complete remission in only around 6 percent of people with melanoma. The treatment kills as many as 2 percent of recipients," a 2014 Nature review on the state of immunotherapy notes.

The therapies work wonders for some — but can kill in rare cases

That seems to be a consistent pattern. Doctors have found that immunotherapies can work wonders in a minority of patients with particular cancers. But they often don't work at all in other patients, and can even send some patients' immune systems into overdrive, causing autoimmune disorders that attack healthy cells. In very rare cases, these treatments can kill.

As Heidi Ledford, the author of the Nature review, states, "After that 1992 approval, researchers and pharmaceutical companies spent years trying to develop new immunotherapies that could produce success stories like Gorman's [the IL-2 patient]. But those attempts failed to live up to their promise in the clinic, leading to decades of frustration."

There are several new immunotherapies now on the market

Right now, many different kinds of immunotherapies for a variety of cancers are in testing. These include treatments that use engineered viruses — HIV, measles, smallpox — to reprogram cells to destroy cancer. (The Vice documentary focuses only on these.) There are also therapeutic cancer vaccines and drugs that get T-cells, the soldiers of the immune system, to work harder to attack cancer.

The types of immunotherapy that appear to be most promising at the moment — the ones that really have the medical community excited — are called "checkpoint inhibitors."

"T-cells are tightly regulated with 'turn on' and 'turn off' signals," explained Dr. Michael Postow, an oncologist who is researching immunotherapies at Memorial Sloan Kettering. Checkpoint proteins do the work of turning them on or off. Checkpoint inhibitors block the body's checkpoint proteins, freeing them to attack cancer.

Even checkpoint inhibitors only work on a fraction of patients, and no one really knows why

One of the first approved checkpoint inhibitors was ipilimumab (brand name Yervoy), an infusion that came to market in 2011 and targets a checkpoint protein called CTLA-4. Ipilimumab was also the first drug to extend the overall survival of patients with advanced melanoma.

The average survival rate for patients on the drug was about 10 months (four months more than those who got a cancer vaccine) — but some people had responses lasting years and counting. Again, however, using the body's immune system to fight cancer isn't always safe: The drug causes severe autoimmune side effects in about 15 percent of patients, and 2 percent (14 people) died as a result of the treatment.

Using the body's immune system isn't always safe

Since 2011, two other drugs have also been approved — nivolumab and pembrolizumab (Carter's medicine) — which target a different molecule, PD-1. These drugs treat advanced melanoma, and nivolumab was also approved for lung cancer.

Drugs targeting the PD-1 pathway have shown responses in a variety of cancers such as melanoma, lung cancer, kidney cancers, bladder cancers, and Hodgkin lymphoma. There are now dozens of clinical trials to test this and other kinds of checkpoint inhibitors for dozens of cancer types.

So these drugs also have promising, but nowhere near perfect, profiles. Take, for example, nivolumab, the checkpoint inhibitor approved for lung cancer. Because the science is new, the long-term data isn't in yet. But so far, researchers found two main effects: Some 15 percent of people saw their cancer shrink away or disappear, and about half of the people who had that response found that it lasted for at least six months.

"Although the fraction of people who respond to these agents is small, the durability of responses when they occur represents a substantial step forward," said Dr. Matthew Hellmann, another Memorial Sloan Kettering oncologist and researcher.

As for side effects, he explained, "The most common experience was that patients feel well. But there can be uncommon side effects, where the immune system attacks other parts of the body — like the thyroid gland — that it shouldn't. In those cases, patients have to be treated with steroids, and some, very rarely, have died."

He continued: "When we talk about using the body’s immune system against cancer, there’s a perception that it is natural and safe." But that isn't always the case.

Research that was recently presented at the American Society of Clinical Oncology meeting in Chicago told a similar story. The New England Journal of Medicine study showed that a combination of two immunotherapies — ipilimumab and nivolumab — and nivolumab alone helped melanoma patients live longer than treatment with ipilimumab only. But a majority of patients (95 percent in the combination group and about 82 percent in the nivolumab group) experienced intense side effects (colitis, diarrhea, and fatigue). Some were so severe, the patients had to discontinue treatment.

Dr. Hellmann has been looking into, among other things, why immunotherapy works better in some patients than in others. He has found that for some immunotherapies, patients who had the most heavily mutated tumors responded best.

This insight has left the field with big questions, including: why do these therapies save some lives and not others? "The critical challenge that we have in the scientific community," said Hellmann, "is to figure out who are the patients most likely to benefit from these treatments and how can we develop better treatments to help those patients less likely to benefit from current immunotherapies."

We're not at the precipice of a "cure"

All the doctors I spoke to were really optimistic about immunotherapies, but had several big caveats.

The dramatic progress has been the simple fact that these drugs work for some periods of time in some patients. And one of the major challenges is to understand why, and who will benefit.

As Dr. Hellmann put it, "I think this is true promise." He pointed to the activity in melanoma research and the three drugs now available to patients. But he also said, "About 15 to 20 percent really benefit from the medicines. It's remarkable — in that the benefit, when it occurs, tends to occur for a long time, but the challenge for us is how you identify those 15 to 20 percent.

"This is the beginning of a really important story," he summed up.

Dr. Padmanee Sharma, a physician-researcher at MD Anderson in Houston, Texas, encouraged patients who are interested to seek out experimental immunotherapies on databases such as clinicaltrials.gov. She said she's never seen anything like the effects immunotherapies are having, but added that it's also very early days, and doctors still need to experiment with combination therapies to find out whether they'd be more effective.

Memorial Sloan Kettering's Dr. Postow said for all the buzz about these drugs right now, there's a lot to be learned: "As excited as we are about this field, we know it doesn't help every patient, and we’re still trying to figure out who it helps, how it helps, and why." He continued: "It’s important for doctors and patients to realize this is not chemo."


TOPICS: Culture/Society
KEYWORDS: cancer; cancercure; cancertherapy; checkpointinhibitors; checkpointproteins; immunotherapy; jimmycartercancer; melanoma
Navigation: use the links below to view more comments.
first previous 1-2021-4041-46 last
To: bert

Regardless of what you or I think of this man personally, he’s 90. Being toast as you put it is pretty much in the cards regardless, he’s lived a long life. If his participating in a clinical trial of Keytruda (the registered trademark name of the immunotherapy in question, the medical name of which escapes me, probably something ending in -mab or -lab) leads to a breakthrough or an improvement in future treatment, then I’m all for it, and he may end up doing some good for others down the road.


41 posted on 08/22/2015 11:58:22 AM PDT by RegulatorCountry
[ Post Reply | Private Reply | To 39 | View Replies]

To: RegulatorCountry

I know...... my goal is 93

I had a very close friend with similar prognosis and none of it helped him


42 posted on 08/22/2015 12:01:14 PM PDT by bert ((K.E.; N.P.; GOPc.;+12, 73, .. Iran deal & holocaust: Obama's batting clean up for Adolph Hitler)
[ Post Reply | Private Reply | To 41 | View Replies]

To: Tired of Taxes

I was diagnosed with a very aggressive bladder cancer one year ago.

My Urologist is convinced that my exposure to radioactivity while in the Army and stationed at Camp Hanford directly across the Columbia river from the 8 nuclear reactors running at several times their designed power levels to create weapons grade plutonium in the 1950s is the major cause.

Two surgeries, followed by 12 BCG treatments, and current biopsies are inconclusive.

BCG is an immunotherapy, and has been around for several years.

Below is a link to some brief information on BCG.

http://emedicine.medscape.com/article/1950803-overview


43 posted on 08/22/2015 12:02:27 PM PDT by B-Cause (The trouble with socialism is that eventually you run out of other people's money - Thatcher)
[ Post Reply | Private Reply | To 1 | View Replies]

To: bert

Immunotherapy is sort of touch and go at this point, as I understand it. If you’re one of the really lucky 15% or so, your tumors disappear or you go into complete remission. 50% or so see a reduction in tumor size and their lives are prolonged, measured in years. The rest see no benefit or even die from complications from side effects, such as the immune system attacking the thyroid.


44 posted on 08/22/2015 12:04:07 PM PDT by RegulatorCountry
[ Post Reply | Private Reply | To 42 | View Replies]

To: B-Cause

Thanks for the info, B-Cause. I hope those inconclusive results mean that the treatments have done their job.


45 posted on 08/22/2015 12:20:40 PM PDT by Tired of Taxes
[ Post Reply | Private Reply | To 43 | View Replies]

To: nascarnation

Not unless Jimmy served in the military for at least 20 years and I believe he only served 4 years, so no Tricare.


46 posted on 08/22/2015 2:08:13 PM PDT by kagnew
[ Post Reply | Private Reply | To 28 | View Replies]


Navigation: use the links below to view more comments.
first previous 1-2021-4041-46 last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson