Had the Indians advanced to iron metallurgy and gunpowder been more advanced in agricultural techniques to feed large populations, developed wealth creation through private property, etc, the outcome would have been different. Still violent. But different.
When unequal cultures meet. Stuff happens. Unpleasant stuff happens. Always has. Always will. Ghengis Khan conquered a lot of far less unequal cultures and unpleasant stuff happened as he remade Asia.
Interesting side note. At the height of the depression, and in 1934, Roosevelt offered the many Indian tribes money to relinquish their sovereignty as nations—a status that the Constitution created.
The tribes that did not take the bribe and relinquish sovereignty (Cherokee, Osage, Shoshones and one other) are today wealthy tribes with free people on their reservations—their reservations have businesses, nice homes and still retain their cultural differences. Most people don’t know it, but Tulsa Oklahoma is Indian reservation.
OTOH, the tribes that took the money and relinquished their sovereignty are run by the Bureau of Indian affairs, live on federal land, are assigned housing, need permission from Washington to open a business and are the most poverty stricken people in the US. (BTW, this is the reason the Keystone pipeline will probably eventually go in. It travels across non-sovereign Indian reservations. They have no say in what the feds put on their land because it isn’t their land).