Congress has been reworking the Constitution since the beginning until it means little today. The best example would be the 2nd amendment.
There have been so many laws put into effect over the years that the true meaning of the 2nd amendment doesn’t even resemble the original intent.
I think the best example is the Commerce Clause. It's been nuanced into an essentially open-ended claim of authority with no objectively discernible limit. You'd be hard pressed to find anything closer to a Constitutional Pandora's Box than Wickard v Filburn.