Don’t know the particulars of this substance, but it sounds like DIC, disseminated intravascular coagulation, which can be caused by several different insults, trauma, infection.
It is a domino effect of abnormal clotting throughout the bloodstream. The clots themselves are small, but there are so many that they basically use up all of the blood’s ability to clot. Then you start bleeding from everywhere.
O2
That sounds like a similar problem which can occur when amniotic fluid enters the blood stream.
Several years ago I broke my back in an auto accident...compression fx of L1. I was supposed to have the bone cement installed the following day, then a 5 day healing phase and I’d be able to go back to work. However, I didn’t have enough insurance coverage at the time to have the surgery.
I still have problems as a result of that break, but after reading the article, I think I’m glad I didn’t. I didn’t know that such a huge risk was involved with the cement. I’ve often thought of having the repair done since now I have insurance to cover it, but I think I’ll leave it alone for now.
Thanks for the article.
Bone cement is acrylic based, MMA, or calcium or magnesium phosphate based. I have seen reports of severe vasoconstriction from calcium phosphate entering systemic circulation. Acrylics will cause clotting but I did not see any conclusive cases where it caused acute DIC.
Usual culprits are multiple emboli, hypersensitivity, transfusion reaction, etc. or just that elderly females are high risk for surgical procedures.
In any case, they violated regulations in this off label use.