This is why the ability to make quick follow up shots is essential. The only really way to take a bad guy out with one shot is to hit them in the head or spinal column. This is quite difficult in the heat of battle. The recent exhaustive FBI report on the defense use of handguns showed that even their best marksmen miss over 75% of their shot in the heat of a battle. That's a major reason they've gone back to 9mm. Range tests on both the best a least proficient shooter show they are much better at quick, accurate follow up shots with a 9 mm.
I did pretty good with 10mm. For some reason s&w got the recoil right , for me, anyway.