Like the days of Noah, we may have an attempt to pollute the image of God in men, by seeing a race of part-”human” and part-animal people.
The last time, we got a Flood. The next time, Fire.
Of Eve, God said- "Her seed will crush your seed." He's talking about genes. I think the Mark will be a lie- take this shot and get super powers, be transformed like a Marvel Superhero, but in reality, you'll become a monster. I don't think it's a coincidence that the Antichrist is also called "The Beast."- "The Animal."