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Global pandemic fear as flu kills man, infects son
Sydney Morning Herald ^ | February 22 2003 | M.A.J. McKenna

Posted on 02/21/2003 9:38:57 AM PST by dead

A strain of flu that jumped from birds to humans has killed a man and infected his son in Hong Kong, alarming health officials who fear that such cases could signal the emergence of a potentially deadly virus.

The World Health Organisation (WHO) has alerted its global influenza surveillance network.

But scientists said the virus had not yet mutated into a form that could pass from human to human, the type which in the past caused global pandemics.

A leading microbiologist in Hong Kong said the virus could cause a pandemic only if it got mixed up with human flu strains.

The illnesses are clustered in a family from Hong Kong that went to China's Fujian province in late January to visit relatives. While there, an eight-year-old daughter became ill and died.

After other members of the family became ill they returned to Hong Kong, where the father, mother, son, a second daughter and a grandfather were admitted to a hospital.

The father died on Sunday. The boy, aged 9, and his 10-year-old sister remain hospitalised. Research into whether the other family members have the same strain of the flu virus as the father and son is continuing.

According to the WHO, the boy and the father were infected with a virus known as influenza H5N1. That strain of virus is common in ducks and causes high rates of death in chickens.

It had never been seen in humans, though, until 1997, when it was diagnosed in a Hong Kong three-year-old.

The virus ultimately brought illness to 18 people and killed six, an unusually high death rate for flu. Health authorities slaughtered all 1.4 million chickens in Hong Kong, hoping to break the chain of transmission between birds and people.

The virus discovered this week in Hong Kong is not exactly the same as the 1997 strain.

Hong Kong's Secretary for Health, Yeoh Eng-kiong, urged residents to stay calm. "The source is direct from poultry, not from humans, so there should be no alarm," Dr Yeoh said.

The Health Department said it was working closely with officials on mainland China, which has denied any links with bird flu cases found in Hong Kong.

The region imports 80,000 live chickens a day from China.

A Health Department spokeswoman said the boy's relatives raised chickens at home.

The cases hint at a pattern familiar to scientists.

Flu viruses change slightly every year. Every few decades, though, they mutate dramatically, producing a significantly different strain to which humans are more vulnerable.

A virus that jumped from animals to humans would produce a significant mutation.

Health authorities will be studying the new H5N1 strain for any sign that it can be transmitted from person to person. The 1997 virus could not be passed between people; all 18 cases came from individual exposures of humans to infected birds.

But there were fears at the time that, if the virus cross-bred with a milder flu that did move from person to person, it could produce a dangerous strain that would move rapidly around the world.

Cox News, The New York Times, agencies


TOPICS: Culture/Society; Foreign Affairs; News/Current Events
KEYWORDS:

1 posted on 02/21/2003 9:38:57 AM PST by dead
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To: dead
"if the virus cross-bred "

EHemm....Cross BREEDING viruses....Unless there has been some radical change of understanding which I am not aware of of Viruses don't breed they replicate. I understand that there is a mechanism by which bacteria may pick up and incorporate genes from their environment but a virus? Anyone know anything about this?

2 posted on 02/21/2003 9:51:40 AM PST by MigrantOkie
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To: MigrantOkie
It is possible for certain viruses to inherit portions of their host's DNA. If a virus manages to infect a host chicken's cell it may just copy a strech of DNA that codes for a protein receptor on the chicken's cell membrane onto itself. Which means the next time the virus infects a chicken it may be adapted to the protein structure of the chickens cell membrane which makes the infection process that much easier. Now how does a chicken virus become a human one, I'm not sure.
3 posted on 02/21/2003 9:57:08 AM PST by NP-INCOMPLETE
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To: MigrantOkie
If you get two viruses in same cell, you can get recombination events between their two different viral genomes leading to a new virus.
4 posted on 02/21/2003 9:58:14 AM PST by realpatriot71 (legalize freedom!)
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To: realpatriot71
Really?....wow....kinda scary...
5 posted on 02/21/2003 10:13:44 AM PST by MigrantOkie
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To: NP-INCOMPLETE
Thanks for the info
6 posted on 02/21/2003 10:14:55 AM PST by MigrantOkie
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To: dead
I can't wait to see how the paranoid from both left and right reacts to this bit of news ...
7 posted on 02/21/2003 10:16:02 AM PST by mgc1122
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To: MigrantOkie
Very sad for that family. One daughter already dead, the father dead and two more children very ill.
8 posted on 02/21/2003 10:16:55 AM PST by justshutupandtakeit (Islame has had its day.)
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To: MigrantOkie
Yeah, it's how the last event terrible bout of "hong kong flu" got started - Pig virus plus normal flu virus. When both viruses infect the same cell(s), there is a chance that during the repackaging of the genome into the capsid that part of one genome and and part of another genomes gets placed inside. Normally this leads to ineffective viruses, but when you are dealing with literally millions and millions of virions, one of these proper recombination events is likely. Once you have that one working recombinant virus you've got a scarry combination, because all you need is one to make the rest.
9 posted on 02/21/2003 10:19:15 AM PST by realpatriot71 (legalize freedom!)
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To: dead
Hmm ... so if someone is sick with a mild flu and catches this virus as well ... it's pandemic time ....

Wonder if can do a flu / common cold species virus jump.

10 posted on 02/21/2003 10:21:34 AM PST by Centurion2000 (Take charge of your destiny, or someone else will)
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To: mgc1122
I can't wait to see how the paranoid from both left and right reacts to this bit of news ...

Yeah any viral infection anywhere is the world must be the work of terrorists . . .

11 posted on 02/21/2003 10:26:16 AM PST by realpatriot71 (legalize freedom!)
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