Those differences can be as profound as skin color and body proportion ordinarily used as the standards to define "race".
Interestingly enough, several of the gene variants that enable the Eskimo to live in the far North are similar in operation to those that allow the Sa'ami to live there, but they affect different genes on the same segment.
Thought I'd mention that because it can become confusing when reading about Sa'ami living on seal and Eskimon living on seal, and how they do that. You really do have to have some "differences" in the way your body handles the surplus iron you are consuming ~ plus, when you put Sa'ami and Eskimos on a modern Western diet they both develop diabetes, heart trouble, alcoholism, and so forth.