Regardless if the CFR for the most part is unconstitutional, it's businesses cutting costs in safety and health resulting in deaths and illnesses as well as monopolies and unreasonably high prices that spurred most of these regulations to begin with.
The FCC for example, is totally unconstitutional. Though I think the FCC is a good idea, congress should not abuse the power given to them by the Constitution and should follow the amendment process to make these laws(regulations).