Arguing publicly with church (APWC) resulted in excommunication/death
APWC resulted in the loss of sovereignty.
APWC resulted foreigners in your lands.
All pretty good reasons, until finally the burden on the conscience became too great, and the worst consequences became bearable when considered against the pain the corruption was causing.
What of the APWC in lands that were NOT orthodox in beliefs? In say Ethiopia or Yemen or the Parthian Empire? Yet they held to the same canon.