There will be those who refuse the mark and most will probably be murdered by those who follow the beast, aka. the antichrist, the tribulation saints will do great exploits for God and Christ Jesus during their time; they are the tribulation saints who will die rather than yield to the beast. It will be a 7 year period of hell on the earth and men will learn at last that the wrath of God abides on all who do not believe on Jesus Christ as Lord and Saviour, athiests and false religion peoples alike. All have sinned, all have come short of the glory of God.
So what should anyone do?