Posted on 02/09/2020 1:03:57 PM PST by BenLurkin
“I read a report the other day that said the cytokine storm is from the body inadequately developing defenses to the virus early on. They said that suppressing fever causes the inadequate defense development and that anti fever medication should not be taken until the fever is 103.5..104.0.
that’s interesting ... here’s a published medical article that discusses that:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786079/
one thing that caught my eye:
“A challenge in ascertaining the precise value of fever in endotherms is that the antipyretics used to inhibit fever target multiple aspects of the inflammatory response besides temperature regulation”
maybe it’s not just the fever suppression that’s the problem but that NSAID’s suppress the general inflammatory response (unlike the non-NSAID, acetaminophen)
also looks like tocilizumab might be an excellent treatment for cytokine storm:
https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0343-9
.
I (think) the source was
over on a thread at Instapundit, writes:
I'm not a doctor, but based on this remark in the Live Science article about the relatively few children who're victims of the Corona virus I will hazard a guess that extends what it says in this remark.
The innate immune system is the first line of defense against pathogens. Cells in that system respond immediately to foreign invaders. (The adaptive immune system, by contrast, learns to recognize specific pathogens, but takes longer to join the battle.) If the innate immune response is stronger in children exposed to 2019 nCoV, they may fight off infection more readily than adults, suffering only mild symptoms.
It seems sensible to assume that the innate immune system protecting a child's lungs must be more effective than that in adults. Their breathing passages are shorter and their adaptive immune system has yet to learn what pathogens to fight. That stronger innate immune response (attacking anything foreign) may give them added protection against a virus like the Corona.
One peculiarity of the Corona virus is that its infection must plant itself well inside our lungs. Throat swabs often fail to detect it. That contrasts with many other viral infections that first settle in our throats and then move to our lungs. A throat infection is uncomfortable but not deadly and gives our adaptive immune system to prepare to fight it before it reaches our lungs, where it can be lethal. Because the Corona virus bypasses our throat and infects our lungs directly, the response of our adaptive immune system is delayed.
Of course, there's also another factor suggested by the article, that the immune system of adults overreacts to a Corona virus infection, making matters worse.
Adults are also more susceptible to a detrimental immune response that causes a condition called acute respiratory distress syndrome (ARDS), said Dr. James Cherry, a professor of pediatrics and infectious diseases at UCLA's Geffen School of Medicine. A complicated imbalance of immune cell activity sends inflammation into the lungs into overdrive, ultimately causing fluid to fill the alveoli, or air sacs, according to research published in the journal Annals of Translational Medicine
ARDS is the primary way that the Corona kills.
It’s similar to how a donor bone marrow transplant works. The effect is called gvhd. The donor cells attack the recipient so organs of varying degrees. I’ve only had it with my eyes. But, my fellow sct/bmt’ers have donor cells attacks lungs, gut, heart, etc
Hence the need for prednisone etc. then there’s a balancing act in not getting sick from lowering the immune system. MS is similar. Their body is attacking itself.
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