Posted on 11/04/2007 6:36:27 PM PST by neverdem
"... I feel like the credibility of my scientific career is sitting on a razor’s edge between ‘Wow, this is really cool,’ and ‘These people are nuts.’”
Hey, he's not the first cat to realize a little buzz will get you boned as well as stoned. But he might be the first one to try it on mice.
I don’t get it. The NY Times article says low frequency, the linked article from Proc. Natl. Acad. Sci. says high frequency, low amplitude. What’s the buzz?
That hormone is osteocalcin. It's a keyword on your thread. Thanks for the reminder for the diabetes list. Type IIs and folks with metabolic syndrome, aka syndrome X, might find this interesting.
Freepmail me if you want on or off of the diabetes ping list.
Go with the PNAS abstract and article. She goofed, although she’s usually one of the Times’ better writers for this stuff.
If that gizmo got results like the article describes publicity
would explode.
I guess this explains why truck drivers are so thin.
LOL! Thanks for the pic!
Imagine the applications of this for space travel.
Bone loss will be a real issue for our Mars astronauts, and can potentially cause problems later in life for our ISS astronauts.
Just stick one of these suckers under their bed-straps and the problem’s solved!
Ok, yea, 90 hz, 0.2g acceleration, 12 micrometer displacement (yikes?). Could build a human sized platform for about $150-$200, I would think, low runs, with high quality components. Add another $50 for computer controlled monitoring. I’d go for it. Crank up production with overseas contracts for under $100 per unit. Tell me it’s not in the near future! Sketched out a design for my personal use. (Damn that clingy adipose tissue).
I assume someone has confirmed that the fat reduction isn’t simply due to buzz-stressed mice eating less?
There are many different ways of cellular signaling in the body. Some involve mechanical connections from cell surface receptors that go all the way to the nucleus and modify gene expression. These can transduce changes in pressure to changes in gene expression. As weird as the results of this research sound, it’s not impossible that controlled manipulation of mechanical transduction systems could have effects on cell expression and function that normally wouldn’t be expected in the “natural” biological context.
Rather than harvesting and storing cells why are we not focusing on the chemicals that induce our own PSCs to mature. We have erythropoietin and a few others. This would reduce the effects of storage and possibilities of auto and alloantibodies. Not to mention some wahoo mixing up your eggs or thawing them improperly.
From the pdf link:
Results
LMMS Suppression of Adiposity in Normal B6 Mice. At baseline, body weights of the LMMS (21.2 1.5 g) and control (CTR) (21.1 1.7 g) mice were similar (P 0.9). Throughout the course of the protocol, body mass of the two groups increased at similar rates (Fig. 1). Activity patterns during the 15 min of LMMS and sham treatment were not noticeably different from their behavior in their cages or from each other. There were no noticeable differences in eating behavior between groups, and weekly food intake between LMMS (26.4 2.1 gweek1) and CTR (27.0 2.1 gweek1) mice was essentially identical (Fig. 1). At 12 weeks, when the in vivo CT scans were performed, the body mass of LMMS animals was not significantly different from CTR (4.0% lower in LMMS; P 0.2) (Table 1).
The pdf didn't translate correctly. is supposed to mean either 'plus or minus', 'equals' or that the last term is a denominator, e.g. 26.4 2.1 gweek1 means 26.4 grams plus or minus 2.1 grams per week. It's on page one.
This is very interesting. When I read the headline, I thought it had something to do with alcohol...:)
My FRiend, you are asking much too much of a NYTimes journalist to either either get it right or state it factually.
Rodent you know someone somewhere had an appropriate pic. :’)
If I photoshopped, I’d have another one featuring a cordless optical mouse... ;’)
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