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Dr. Niklas Klümper and Dr. Jonas Saal demonstrated a significant improvement in predicting the response to therapy in metastatic renal cell carcinoma by incorporating the level of inflammation, which was assessed using two straightforward blood parameters, alongside the conventional imaging-based approach. The research group led by Dr. Klümper has now been able to show that the investigation of two inexpensive and widely available inflammatory markers in the blood (C-reactive protein (CRP) and albumin) significantly improves the prediction of therapy response in patients with metastatic renal cell carcinoma, especially in the large group of patients with disease control in the first...

Researchers have long known that moderate exercise has a beneficial impact on the body's response to inflammation, but what's been less understood is why. New research done on a mouse model suggests that the answers may lie at the production level of macrophages—white blood cells responsible for killing off infections, healing injury and otherwise acting as first responders in the body. "Much like if you train your muscles through exercise, we showed that exercise of moderate intensity ended up training the precursors of those macrophages in the bone marrow," says Ali Abdul-Sater. "The way that exercise is doing this is...

A study conducted by the US Centers for Disease Control and Food and Drug Administration has shown that the risk of myocarditis following mRNA COVID vaccination is around 133x greater than the background risk in the population. This means Covid vaccination increases the risk of suffering myocarditis, an autoimmune disease causing inflammation of the heart, by 13,200%. ... The study, conducted by researchers from the U.S. Centers for Disease Control (CDC) as well as from several U.S. universities and hospitals, examined the effects of vaccination with products manufactured by Pfizer-BioNTech and Moderna. The study’s authors used data obtained from the...

Researchers found that drinking a 60ml turmeric drink twice a day allowed players to return to their pre-game fitness faster than those who did not. Playing soccer causes muscle damage in players and an inflammatory response—and their rapid recovery is crucial to optimizing their next performance and reducing injury risk. The active ingredient in turmeric is curcumin—known to have anti-inflammatory properties—and previous studies have found that curcumin supplementation can reduce soreness following muscle-damaging exercise. This process appears to be aided by a reduction in pro-inflammatory proteins in the blood, known as cytokines, which increase in response to a stress, such...

A new study found a pro-inflammatory diet is associated with an increased risk of relapse in multiple sclerosis (MS) patients. The researchers found a more pro-inflammatory diet is associated with a higher risk of relapses and more inflammatory brain lesions for MS patients in the years following their first disease attack. MS is an autoimmune disease characterized by chronic inflammation that can damage nerve cells. A pro-inflammatory diet as per the study includes foods containing high amounts of fats and proteins. These foods are thought to drive chronic inflammation and immune dysregulation that could affect the course of MS. The...

A study analyzes in old rats the effects of a calorie-restricted diet on the hippocampus, a brain structure that is critical in learning and memory processes. The results corroborate that there is a cognitive improvement derived from diet, linked to a reduction in the levels of inflammation and neuronal loss in the hippocampus. It has been described that some of the brain alterations observed during aging are related to the cognitive dysfunction that manifests naturally as we age. These processes, which depend on both genetic and environmental factors, are particularly important in the hippocampus. Calorie-restricted diets have been shown to...

With the passage of time, our body’s repair systems break down; nasty glitches accumulate in our DNA and proteins, metabolism stutters, and cells stop dividing. We are all on a slippery slope to the grave, but research in worms, flies, mice, and monkeys shows that there is nothing inevitable about how fast we slide. Dietary and lifestyle changes – and, perhaps, anti-aging drugs – can slow aging and boost our span of healthy years. A new discovery suggests that a protein in the brain may be a switch for controlling inflammation and, with it, a host of symptoms of aging....

Consuming a diet rich in vitamin A or its analogs may help prevent children and young adults with acute lymphoblastic leukemia (ALL) reduce their risk of developing painful pancreas inflammation during chemotherapy treatment. For people with ALL, treatment with the enzyme asparaginase helps starve cancer cells by reducing the amount of asparagine circulating in the blood, which the cancer cells need but cannot make themselves. The medication, often used in combination with other chemotherapies, is given via injection into a vein, muscle, or under the skin. However, an estimated 2% to 10% of asparaginase users develop inflammation of the pancreas...

New evidence released today from a study of 31,245 patients already taking statin therapy indicates that inflammation may be a more powerful predictor of risk of future cardiovascular events—such as heart attack and stroke—than "bad" cholesterol. Treatments that aggressively lower vascular inflammation need to be incorporated into daily practice if doctors are to maximize patient outcomes, according to the study's corresponding author, Paul Ridker, MD. Said Ridker: "In our study of patients already taking a statin, hsCRP—a measure of residual inflammatory risk—was a more powerful determinant of having a future heart attack or dying from cardiovascular disease than was LDL-cholesterol—a...

Researchers have provided important molecular understanding of how injury may contribute to the development of a relatively rare but often aggressive form of brain tumor called a glioma. The UCL team have now identified a possible mechanism to explain this link, implicating genetic mutations acting in concert with brain tissue inflammation to change the behavior of cells. Professor Parrinello said, "Normally astrocytes are highly branched, but we found that without p53 and only after an injury the astrocytes had retracted their branches and become more rounded. They weren't quite stem cell-like, but something had changed. So we let the mice...

Urolithin A, a metabolite of ellagitannins in pomegranates, boosts immune cells’ ability to combat tumors by inducing a process known as mitophagy. STORY AT-A-GLANCE Urolithin A (UA) has emerged as a powerhouse player in the fight against cancer, as it may naturally boost tumor-fighting immune cells. UA is a metabolite of ellagitannins in pomegranates that has anti-inflammatory and anticancer effects. UA “recycles and renews mitochondria” by inducing a biological pathway known as mitophagy—the process of cleaning out your mitochondria, allowing them to function at their best. This changes T cells’ genetic program, making them more able to fight tumors. In...

Oral mucositis is a mucosal alteration that usually arises from oncological treatments, such as chemotherapy, and it is characterized as an inflammatory process. In this study, researchers aimed to demonstrate the chromatographic constitution of Andiroba oil, while comparing and evaluating andiroba oil and laser scarring efficiency in treatments of oral mucositis (OM) in hamsters. The researchers write, "The low-level laser therapy (LLLT) is the best standard treatment and the most efficient method in treating OM. Similarly, the andiroba oil presents great potential for the treatment of inflammatory diseases." The animals were submitted to 5-Fluorouracil. Included in the study were 122...

Story at-a-glance: * A carnivore or meat-only diet can be uniquely beneficial for some people, especially those struggling with autoimmune diseases, Crohn’s disease, ulcerative colitis, chronic pain and mental health disorders * It can also be used as a detox strategy for three to 12 months * One of the primary benefits of a carnivore diet — as long as you focus on red meat and limit chicken and pork — is that it’s a really low in omega-6 fat, which is the most harmful type of fat and a primary driver of chronic disease * You’re also removing most...

At a conference for medical professionals in Sedona, Arizona this past weekend, several speakers–all physicians–commented on a disturbing trend: an increase in otherwise healthy people dying in their sleep.Sudden unexplained age-inappropriate deaths seem to be happening more than usual, both in the United States, where these medical doctors practice, and in several other countries in the industrialized world.Excess death “is a phenomenon all over the world at the moment,” said Dr. John Campbell, a nurse educator who has been meticulously following and commenting on the scientific data for his YouTube channel, which has 2.47 million subscribers.The data shows that “deaths...

Older people who were infected with COVID-19 show a substantially higher risk—as much as 50% to 80% higher than a control group—of developing Alzheimer's disease within a year, according to a study of more than 6 million patients 65 and older. Researchers report that people 65 and older who contracted COVID-19 were more prone to developing Alzheimer's disease in the year following their COVID diagnosis. And the highest risk was observed in women at least 85 years old. The findings showed that the risk for developing Alzheimer's disease in older people nearly doubled (0.35% to 0.68%) over a one-year period...

Recent autopsy data supports an association between COVID mRNA “vaccines” and heart inflammation, rather than a link between the COVID virus itself and such adverse effects.On Sunday, The Daily Sceptic highlighted a growing body of autopsy studies that “repeatedly affirm” that the COVID-19 mRNA shot caused myocarditis, or heart inflammation, which in turn led to death in the cases studied.One study, shared August 1, concluded that two teenage boys died “shortly” after their Pfizer mRNA jab due to “myocardial injury,” echoing two other reports which identified myocarditis as the cause of death following COVID “vaccination.” A review of data from...

Inflammation is an essential part of the body's healing process. But when it persists, it can contribute to a wide range of complex diseases including type 2 diabetes, heart disease, and autoimmune diseases. Now, research shows a direct link between low levels of vitamin D and high levels of inflammation, providing an important biomarker to identify people at higher risk of or severity of chronic illnesses with an inflammatory component. The study examined the genetic data of participants in the UK Biobank, using Mendelian randomization to show the association between vitamin D and C-reactive protein levels, an indicator of inflammation....

Research in people with heart disease risk factors has shown that consuming green tea extract for four weeks can reduce blood sugar levels and improve gut health by lowering inflammation and decreasing "leaky gut." Researchers said this is the first study assessing whether the health risks linked to the condition known as metabolic syndrome, which affects about one-third of Americans, may be diminished by green tea's anti-inflammatory benefits in the gut. In the new study, green tea extract also lowered blood sugar, or glucose, and decreased gut inflammation and permeability in healthy people—an unexpected finding. "What this tells us is...

Two new treatments for Crohn's disease showed roughly equal performance in a clinical trial. This allows clinicians and patients to make treatment choices based on tolerance, according to Stephen Hanauer, MD. Crohn's disease (CD) is a chronic, progressive inflammatory bowel disease, causing abdominal pain, weight loss and fatigue. Treatment for CD has typically focused on alleviating symptoms to achieve clinical remission using corticosteroids or immunomodulators, but a need for more effective treatment remains. "While there are numerous therapies and mechanisms of action for drugs approved for moderate-severe Crohn's disease there has been a therapeutic ceiling as far as outcomes are...

Several minor cannabinoids contained in the cannabis plant "strongly inhibit" the activation of human immune cells that lead to chronic inflammation, according to physiologists at The Queen's Medical Center of Hawaii. The study also revealed the strongest inhibitory cannabinoid, cannabigerolic acid, disrupts a key mechanism that allows calcium ions to enter and activate immune cells. As a result, cannabigerolic acid suppresses the spread of inflammatory signals. Chronic inflammation is a biological process in which inflamed tissues release messenger molecules called cytokines. These cytokines recruit immune cells that become activated and maintain the inflammatory response. This chronic inflammation initiates or exacerbates...