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The decades-long quest to develop a HIV vaccine has been dealt another major blow, with the 'last true candidate in development' failing to prevent infections any better than a placebo in late-stage clinical trials. The multinational Mosaico study, which began in 2019 and involved more than 3,900 volunteers, was investigating a four-shot HIV vaccine for cisgender men and transgender people who have sex with cisgender men and/or transgender people. As the US National Institute of Allergy and Infectious Diseases (NIAID) reported last week, the trial was stopped after a planned data review by the study's independent data and safety monitoring...

CHARLOTTESVILLE, Va. (WVIR) - Doctor Patrick Jackson with the University of Virginia has advice for people looking to get vaccinated. Dr. Jackson says COVID-19 vaccines have a very low Myocarditis or heart inflammation risk, however the risk is highest in young men. He says says the Johnson & Johnson vaccine does not have any association with this side effect and could be the best choice for some. “Now that we have more data about these vaccines people can talk to their doctors about which vaccine might be the ideal one for them, or even now that we have some flexibility,...

(CNN)Using the Johnson & Johnson vaccine as a booster for people initially immunized with the Pfizer/BioNTech vaccine produces a strong immune response and may do more to elicit protection against severe disease, researchers reported Sunday. Their small study of 65 volunteers who all initially got two doses of Pfizer/BioNTech's vaccine showed that using the J&J Janssen vaccine as a booster produced a slower but more sustained antibody response against the original strain of the virus, as well as the Delta and Beta variants, they said.... ...after four weeks, antibody levels began to drop off in people who got boosted with...

Food and Drug Administration scientists found potential benefit to a second dose of the Johnson & Johnson coronavirus vaccine in a data review that was released Wednesday and that depended heavily on the company’s analysis, suggesting a booster of that shot was perhaps more warranted than additional doses of other coronavirus inoculations. From the dawn of the vaccine campaign, many experts said they believed the one-shot Johnson & Johnson regimen would ultimately require a second shot, and the documents pave the way for a panel of experts who advise the FDA to discuss Friday the timing, necessity and safety of...

"The Janssen COVID-19 Vaccine’s Local Reactions, Systemic Reactions, Adverse Events, and Serious Adverse Events" "Fever was more common in participants 18-59 years (12.8%) compared to those ≥60 years (3.1%). The majority of systemic reactions were mild or moderate in severity. The most common grade 3 reactions were fatigue and myalgia." "Among vaccine recipients aged 18-59 years, 26.4% reported using antipyretic or analgesic medications, compared to 6.0% of placebo recipients. Among vaccine recipients aged ≥60 years, 9.8% reported using antipyretic or analgesic medications, compared to 5.1% of placebo recipients." "Reports of embolic and thrombotic events had a slight numerical imbalance with...

Johnson & Johnson: Children Don’t Need the [bleeping] COVID Vaccine Because There Are ‘Unknown Repercussions Down the Road’ … Want to ‘Punish’ Unvaccinated Adults and Turn Them Into ‘Second-Grade Citizens’ for Not Complying with MandatesBrandon Schadt, Johnson & Johnson Regional Business Lead: “It’s a kid, you just don’t do that, you know? Not something that’s so unknown in terms of repercussions down the road, you know?” Schadt: "Kids shouldn't get a [bleeping] [COVID] vaccine." Schadt: “It’s a kid, it’s a [bleeping] kid, you know? They shouldn’t have to get a [bleeping] [COVID] vaccine, you know?” Schadt: “J&J is like stepping...

‘Vast majority’ of Covid-19 cluster in Cape Cod were vaccinatedIn Cape Cod, a geographic cape extending into the Atlantic Ocean in Massachusetts, the vaccinated are falling ill with Covid-19. The American town with one of the highest vaccination rates in the state, now has the highest rate of new cases. An official told ABC News on Monday that the “vast majority” of the 132 Covid-19 cases were among vaccinated individuals. At least 33 people in a nursing home in Yarmouth on Cape Cod have tested positive for SARS-Cov-2. Most of the residents that tested positive were vaccinated, reported the Boston...

(h/t Cathi)EMA’s safety committee (PRAC) has recommended that people who have previously had capillary leak syndrome must not be vaccinated with COVID-19 Vaccine Janssen. The Committee also recommended that capillary leak syndrome should be added to the product information as a new side effect of the vaccine, together with a warning to raise awareness among healthcare professionals and patients of this risk.The Committee reviewed 3 cases of capillary leak syndrome in people who had received COVID-19 Vaccine Janssen, which occurred within 2 days of vaccination. One of those affected had a history of capillary leak syndrome and two of them...

Employers may be liable for ‘any adverse reaction’ from mandated coronavirus shots: OSHAIt’s also possible that employers requiring the injections may be held legally liable for violating federal law.WASHINGTON, D.C., May 10, 2021 (LifeSiteNews) — The federal Occupational Safety and Health Administration (OSHA) has put employers on notice that should they attempt to require employees to receive injections of experimental COVID-19 gene-therapy vaccines a resulting adverse reaction will be considered “work-related” for which the employer may be held liable.OSHA released its new guidance on April 20 under a “Frequently Asked Questions” section of its website having to do with COVID-19...

Johnson & Johnson's coronavirus vaccine rollout hit several unfortunate snags this week — some far worse than others. The New York Times reported on Tuesday that 62 million of the company's vaccine doses must be checked for contamination, following an error at a Maryland manufacturing plant that already ruined 15 million doses. The plant's workers accidentally mixed up some vaccine ingredients last month. Then a vaccination site in Colorado, three sites in North Carolina, and one in Georgia all temporarily stopped administering Johnson & Johnson's shot after about 45 people in total experienced minor adverse reactions involving nausea, dizziness, fainting,...

An extended thread topic. Discussion of the different Covid vaccines. Comparisons. Contrasts. Pros. Cons. Firsthand experiences, scientific insights, etc... ** The current vaccines available on the market are: 1) Pfizer/BioNTech (mRNA) 2 doses 2) Moderna (mRNA) 2 doses 3) Johnson & Johnson aka Janssen (DNA adenovirus vector) 1 dose (And for those with any experience or expertise regarding some of the additional ones avail overseas, feel free to contribute as well! Note: none of the below employ mRNA technology.) - AstraZeneca (British/Swede collab) - SinoVac (China-developed) - Sputnik V (Russia-developed)

Johnson & Johnson should come close to hitting its target of delivering 20 million doses of its one-shot COVID-19 vaccine in March after its shipments stalled in recent weeks, a top White House official said on Monday (22 Mar)... The company shipped four million shots in early March but its rollout has since stalled as facilities involved in the manufacturing await clearance from the U.S. Food and Drug Administration. ...far less than the 20 million it promised to deliver by the end of March... J&J did not immediately respond to requests for comment. Initial U.S. doses have been made at...

Johnson & Johnson is on track to roll out its single-shot coronavirus vaccine in March, and expects to have clear data on how effective it is by the end of this month or early February, the U.S. healthcare company's chief scientific officer said... Interim results from the company's Phase I/II study, published on Wednesday in the New England Journal of Medicine, have helped boost that confidence. The study showed that 90% of 805 volunteers aged 18 to 55 developed protective antibodies 29 days after a single dose, and that increased to 100% by day 57. The study is ongoing, but...

An Atlanta kidnapping crew scheming to nab a North Carolina prosecutor went to the wrong address and, instead, grabbed the attorney’s father, authorities said. Prosecutors said a hired crew was contracted to snatch his daughter, Wake County, N.C., Assistant District Attorney Colleen Janssen, at the behest of a man she had put in prison for life. Twice, apparent bungling led the cohorts to the wrong place, according to the indictment obtained by The Atlanta Journal-Constitution. In March, an Internet search led the alleged conspirators to an address for the North Carolina prosecutor … in Louisiana. So an armed team rented...

Movie: "I Spy" Official Site: Sony.com Director: Betty Thomas Distributed by: Columbia Pictures Theatrical Release Date: November 1, 2002 When the Switchblade, the most sophisticated prototype stealth fighter created yet, is stolen from the U.S. government, one of the United States' top spies is called to action. What he doesn't expect is to get teamed up with a cocky civilian World Class Boxing Champion on a dangerous top secret espionage mission. Their assignment: using equal parts skill and humor, catch one of the world's most successful illegal arms dealers, and foil his treacherous plans for the plane. Cast: Eddie Murphy,...