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Nature has recently published an interesting paper which places severe limits on Darwinian evolution. The manuscript, from the laboratory of Joseph Thornton at the University of Oregon, is titled, “An epistatic ratchet constrains the direction of glucocorticoid receptor evolution.” The work is interpreted by its authors within a standard Darwinian framework, but the results line up very well with arguments I made in The Edge of Evolution. This is the second of several posts discussing it. Using clever synthetic and analytical techniques, Bridgham et al (2009) show that the more recent hormone receptor protein that they synthesized, a GR-like protein,...

Probably almost everyone is familiar with the hyperinflationary episode that engulfed Germany after the First World War. That nation’s economy was crippled by monetary problems that resulted in dreadful personal hardships, even though up to that time Germany had achieved one of the highest living standards in the world. The newly formed German government, named for the city where their constitution was drafted after the Kaiser’s abdication in 1918, kept pumping up the money supply. The process started relatively slowly, but quickly the pace of money creation accelerated. The Weimar government was paying its bills on credit – just like...

Outrageous! Forget everything that you’re hearing about the so called Swine Flu it is not a influenza that originated in swine or any animal for that matter this is a genetically concocted “reassortant” virus that was made by the Centers for Disease Control and Prevention CDC and the World Health Organization WHO. This is a hybrid virus made to order by the WHO and the CDC so that their “boy who cried wolf” scenarios for a worldwide pandemic could be realized.