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Gut microbiota or the population of microbial inhabitants in the intestine, plays a key role in digestion and maintenance of overall health. Intestinal microbes metabolize dietary components into beneficial fatty acids (FAs), supporting metabolism and maintaining host body homeostasis. Metabolites originating from polyunsaturated fatty acids (PUFAs), influenced by gut microbes such as Lactobacillus plantarum, exhibit potent effects on inflammation and immune responses. The researchers used antigen-stimulated spleen cells to elicit an enhanced immune response. Subsequently, they investigated the impacts of different polyunsaturated fatty acid (PUFA) derivatives, focusing on metabolites of linoleic acid, a prevalent dietary fatty acid. Their findings revealed...

Urine levels of adenine, a metabolite produced in the kidney, are predictive and a causative biomarker of looming progressive kidney failure in patients with diabetes, a finding that could lead to earlier diagnosis and intervention, researchers reported. The study results are significant because until now, the most important marker for kidney disease has been protein (or albumin) in the urine. Up to half of diabetes patients who develop kidney failure never have much protein in their urine. As 90% of patients with diabetes (more than 37 million patients in the U.S.) remain at increased risk despite low levels of albumin...

Chemical 'fingerprint' in the blood could provide clues to health later in life Metabolites indicate future lung function, bone density, and blood pressure Could pave the way for new treatments for age related conditionsA revolutionary new blood test could tell you how long you will live, and how quickly you will age. Scientists have discovered a chemical ‘fingerprint’ in the blood that may provide clues to an infant's health and rate of ageing near the end of life. The discovery raises the prospect of a simple test at birth that could help doctors stave off the ravages of disease in...