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You Get What You Pay For? Costly Placebo Works Better Than Cheap One ScienceDaily (Mar. 5, 2008) — A 10-cent pill doesn't kill pain as well as a $2.50 pill, even when they are identical placebos, according to a provocative study by Dan Ariely, a behavioral economist at Duke University. "Physicians want to think it's the medicine and not their enthusiasm about a particular drug that makes a drug more therapeutically effective, but now we really have to worry about the nuances of interaction between patients and physicians," said Ariely, whose findings appear as a letter in the March 5...

Not all placebos are created equal, according to a new study. In a rare trial pitting two fake treatments against each other, researchers have found that a sham acupuncture technique provided more pain relief than a dummy pill. The two nontreatments also caused different "side effects." Placebo effects have been reported with pills, injections, and even surgery. Previous research hinted that some treatments might elicit stronger placebo effects than others, but the idea hadn't been rigorously tested, says Ted Kaptchuk, the researcher at Harvard Medical School in Boston who led the current study. Kaptchuk and colleagues recruited 270 people with...

Makers of popular antidepressants such as Paxil, Zoloft and Effexor have refused to disclose the details of most clinical trials involving depressed children, denying doctors and parents crucial evidence as they weigh fresh fears that such medicines may cause some children to become suicidal. The companies say the studies are trade secrets. Researchers familiar with the unpublished data said the majority of secret trials show that children taking the medicines did not get any better than children taking dummy pills. Although the drug industry's practice of suppressing data unfavorable to its products is legal, doctors and advocates say such secrecy...

Makers of popular antidepressants such as Paxil, Zoloft and Effexor have refused to disclose the details of most clinical trials involving depressed children, denying doctors and parents crucial evidence as they weigh fresh fears that such medicines may cause some children to become suicidal. The companies say the studies are trade secrets. Researchers familiar with the unpublished data said the majority of secret trials show that children taking the medicines did not get any better than children taking dummy pills. Although the drug industry's practice of suppressing data unfavorable to its products is legal, doctors and advocates say such secrecy...