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MRI of the prostate, combined with a blood test, can help determine if a prostate lesion is clinically significant cancer, research suggests A new meta-analysis suggests doctors and patients can avoid unnecessary prostate biopsies by combining MRI of the prostate findings with prostate-specific antigen (PSA) density. To doctors, clinically significant prostate cancer (csPCa) is prostate cancer that has a high chance of threatening a patient's life. MRI of the prostate can provide some of this information. Still, a biopsy is traditionally needed to determine how aggressive the cancer cells look. This study tested a new approach: combining MRI-based prostate imaging...

New urine-based test looks at 18 genes and was specifically developed to pick out those cancers that need immediate treatment over the slow-growing type. Researchers at the University of Michigan Rogel Cancer Center have developed a new urine-based test that addresses a major problem in prostate cancer: how to separate the slow-growing form of the disease unlikely to cause harm from more aggressive cancer that needs immediate treatment. The test, called MyProstateScore2.0, or MPS2, looks at 18 different genes linked to high-grade prostate cancer. In multiple tests using urine and tissue samples from men with prostate cancer, it successfully identified...

The largest study to date investigating a single invitation to a PSA blood test to screen for prostate cancer has found it had a small impact on reducing deaths, but also led to overdiagnosis and missed early detection of some aggressive cancers. The CAP trial, published in the Journal of the American Medical Association (JAMA) and carried out by researchers from the universities of Bristol, Oxford and Cambridge, involved over 400,000 men aged 50-69. Just under half received a single invitation for a PSA test as part of the trial. After following up for 15 years, there was a small...

King Charles has been diagnosed with a form of cancer, says Buckingham Palace. It is not prostate cancer, but was discovered during his recent treatment for an enlarged prostate. The type of cancer has not been revealed, but according to a palace statement the King began "regular treatments" on Monday. Buckingham Palace says the King "remains wholly positive about his treatment and looks forward to returning to full public duty as soon as possible".

Combining testosterone-blocking drugs in patients with prostate cancer relapse prevents the spread of cancer better than treatment with a single drug, a multi-institution, Phase 3 clinical trial led by researchers has found. The approach can extend the time between debilitating drug treatments without prolonging the time it takes to recover from each treatment. Prostate cancer is usually treated with one of several testosterone-lowering drugs for a set period of time. "This adds to a growing body of evidence in favor of more intensive testosterone-blocking therapy in patients with higher-risk prostate cancer," said Rahul Aggarwal, MD. The new study focused on...

Men with high-grade prostate cancer and low prostate-specific antigen (PSA) levels have a poor prognosis. The question remains as to whether the chemotherapy drug docetaxel, which increases survival in metastatic prostate cancer, can improve the cure rate in these patients. In a new study by investigators from Brigham and Women's Hospital, a meta-analysis of five prospective randomized clinical trials (RCTs) found that adding docetaxel to standard-of-care (SOC) treatment was associated with a 70% reduction in death from prostate cancer-specific mortality (PCSM). Investigators performed a meta-analysis of the RCTs evaluating SOC treatment with radiotherapy and androgen deprivation therapy or with radical...

A newly established PSMA PET scoring system can successfully predict whether metastatic castration-resistant prostate cancer (mCRPC) patients will respond to treatment with 177Lu-PSMA therapy. International, multicenter testing demonstrated the effectiveness of the tumor-to-salivary gland ratio (PSG score), which can easily be applied clinically with substantial reproducibility. The recently FDA-approved radiopharmaceutical therapy 177Lu-PSMA has been shown to reduce the risk of death by 38 percent and the risk of progression by 60 percent in mCRPC patients. "Patients do not respond uniformly to this treatment, however," said Masatoshi Hotta, MD, Ph.D. "Identification of patients who will benefit remains an unmet clinical need."...

Urolithin A, a metabolite of ellagitannins in pomegranates, boosts immune cells’ ability to combat tumors by inducing a process known as mitophagy. STORY AT-A-GLANCE Urolithin A (UA) has emerged as a powerhouse player in the fight against cancer, as it may naturally boost tumor-fighting immune cells. UA is a metabolite of ellagitannins in pomegranates that has anti-inflammatory and anticancer effects. UA “recycles and renews mitochondria” by inducing a biological pathway known as mitophagy—the process of cleaning out your mitochondria, allowing them to function at their best. This changes T cells’ genetic program, making them more able to fight tumors. In...

Declines in prostate-specific antigen (PSA) level after treatment with enzalutamide predict improved survival rates in men with non-metastatic castration-resistant prostate cancer (nmCRPC). PROSPER trial data used to explore enzalutamide's effects on PSA levels The researchers analyzed data from the PROSPER trial, published in 2018, which enrolled men with nmCRPC and rapidly rising PSA levels. Increases in PSA signal an increased risk that the cancer will spread, or metastasize, outside of the prostate gland. In patients with nmCRPC, rising PSA levels are often the first sign that the cancer is growing. The 'castration-resistant' part of nmCRPC means that the cancer no...

EW YORK (AP) — New York City residents are accustomed to warnings about all kinds of potential threats — severe weather, public health, mass shootings. But a new PSA on surviving a nuclear attack has rattled some cages. Released this week by the city’s emergency management agency, the 90-second video advises citizens to stay indoors and wash off any radioactive dust or ash. It opens on a computer-generated street, devoid of life. Damaged skyscrapers can be seen in the background.

On Monday, the city of New York launched a new public service announcement (PSA) that provides guidelines about what residents should do in the event of a nuclear attack. Unfortunately, New Yorkers who watch the PSA will likely be severely ill-prepared should a nuclear weapon detonate in their vicinity, as the video provides little in the way of specifics or useful information. Instead, the short clip instructs citizens to follow a rudimentary 3 step plan that leaves them completely reliant on the powers that be to come to the rescue. According to the PSA, New Yorkers should 1) “Get inside”...

Jack Posovic 🇺🇸 @JackPosobiec NYC has just released a nuclear attack PSA Guess they’re worried about Biden as president too

We investigated the possible relationship between boron exposure and prostate cancer (PCa) for men living and being employed at boron mines in villages with rich boron minerals. Out of 456 men studied, 159 were from villages with rich boron sources and boron levels in drinking water of >1 mg L(-1) and these men formed the study group, while 63 from villages with rich boron sources and boron levels in drinking water of <1 mg L(-1) were enrolled into control group 1. A further 234 subjects from other villages with no boron mines were considered as control group 2. Prostate specific...

Prostate-specific antigen (PSA) is a serine protease and one of the most abundant proteins secreted by the human prostate epithelium. PSA is used as a well-established marker of prostate cancer. The involvement of PSA in several early events leading to the development of malignant prostate tumors has made it a target for prevention and intervention. It is thought that PSA cleaves insulin-like growth factor binding protein-3 (IGFBP-3), providing increased local levels of IGF-1, leading to tumor growth. Separately, there are data that suggest an enzymatic regulatory role for dietary boron, which is a serine protease inhibitor. In this study we...

The NFL will air its first public service announcement on sports betting during the Dallas Cowboys vs. New Orleans Saints game Thursday night. The straightforward 30-second PSA features retired coach Steve Mariucci emphasizing the NFL's core message on responsible gambling: "Stick to your game plan. Always bet responsibly." "Getting the tone where you'll get people's attention, so it's not just lost in the flow of TV ads, but also having a clear, supportive tone was important," Chris Halpin, NFL chief strategy and growth officer, who is overseeing the league's approach to sports betting, told ESPN. Halpin said, to start, the...

NBC propagandist calls the Secret Service on Palmetto State Armory for selling AR lowers engraved with Let’s Go Brandon.

CINCINNATI, OH—As part of a campaign to raise awareness and improve public knowledge on treatment options, CNN aired an hour-long public service announcement on the warning signs of dementia Wednesday night. The PSA, which ran over an hour, showed tragic footage of an old man ranting and making nonsensical, confusing statements. CNN says they hope the footage will encourage family members of the elderly to get them tested for the early warning signs of dementia. The cable news channel displayed a phone number for a hotline people can call if they believe someone they know might be suffering from symptoms...

Earth Day, the annual day of environmental action and awareness, was first held on April 22, 1970. This past April 22nd, we finally ventured into the woods behind our house and pulled 4 putrid truck tires/mosquito farms out of the mud, along with about 200 pounds of scrap metal, engine parts, and farm equipment. The place used to be a dairy farm, and I guess "out of sight" was "out of mind". If it were still the 70's, cleaning up the woods would have been "outta sight" in a whole different way. Here's a clip of The Crying Indian from...

A controversial new public service announcement from Cartoon Network encourages children to "see color" when they look at other kids. Only by looking through the lens of color, it says, can a person learn to be anti-racist. "It's important to see people in all their beautiful colors. When you see color and the unique experiences that come from it, you can recognize the role racism plays in our culture and appreciate everyone and their diversity," reads the description of the ad written by the creator of "Steven Universe."https://www.youtube.com/watch?v=zJkVgGYm4xo&feature=emb_title In the ad, a white and black character, along with a purple...

Remember when the Internet and TV commercials and public service announcements were all filled with healthcare workers holding up signs that said “We’re Here For You, Stay Home for Us”? Do you remember all that emotional blackmail? It was all over the place. The message was basically this: Dear Ungrateful Commoner: We’re out here risking our lives on the front lines, and we selfless and brave healthcare heroes need you to remain on lockdown and lose your jobs and your businesses and give up everything that makes life living, for us… Cuz we’re brave and awesome, so we need you...