It took you only 'til your second post to descend.
It's irrelevant in any case, carry on. You had no credibility the moment you made that comment, so all the rest is Nada.
When you are in a hole, it's always a good idea to stop digging.
Posted on 12/27/2005 7:26:46 AM PST by billorites
Marijuana--or more specifically its active ingredient, tetrahydrocannabinol--has a well-documented tendency to stimulate hunger. And while scientists have traced this property to cannabinoid receptors in the brain, they have had little understanding of the neural circuitry underlying this effect.
Understanding this circuitry has important practical implications because blocking the cannabinoid receptor, CB1, offers a promising approach to treating obesity. One such compound, rimonabant (trade name AcompliaTM) is already undergoing clinical testing.
In an article in the December 22, 2005, issue of Neuron, Young-Hwan Jo and colleagues report how the circuitry of CB1 is integrated with signaling by the appetite-suppressing hormone leptin. The CB1 receptor is normally triggered by natural regulatory molecules, called endocannabinoids.
In their studies, the researchers concentrated on the lateral hypothalamus (LH) of the brain, known to be a center of control of food intake. Their studies involved detailed electrophysiological measurements of the effects of specific neurons that they had identified in previous studies as being important in endocannabinoid signaling.
Their studies revealed that activation of CB1 receptors, as by endocannabinoid molecules, induced these neurons to be rendered more excitable by a mechanism called "depolarization-induced suppression of inhibition" (DSI).
What's more, they found that leptin inhibits DSI. However, they found that leptin did not interfere with the CB1 receptors themselves. Rather, leptin "short-circuits" the endocannabinoid effects by inhibiting pore-like channels in the neurons that regulate the flow of calcium into the neurons. Such calcium is necessary for the synthesis of endocannabinoids.
In further studies of mice genetically altered to be leptin deficient, the researchers found the DSI to be more prolonged than in normal mice. Thus, they said, the findings "implicate this mechanism for leptin receptor/endocannabinoid signaling in contributing to the maintenance of weight balance...." The researchers also included that "upregulation of endocannabinoid signaling in the LH may explain, at least in part, the increased body weight consistent with a prior report of elevated endocannabinoids" in such leptin-deficient mice.
The researchers concluded that their findings "are consistent with the hypothesis that the integration of endocannabinoid and leptin signaling regulates the excitability of neurons on appetite-related circuits."
They also wrote that "the cellular mechanisms of recently developed antiobesity drugs, such as rimonabant, may include decreased endocannabinoid signaling and hence decreased excitability of LH circuits related to appetite, even in the context of leptin insufficiency or resistance."
I repudiate that. Overt name calling, yes, but in response to the covert name calling directed at me below:
"This sounds like the liberal attitude toward guns. Is this your take on guns as well? Why are you at Free Republic?"
I don't feel any contrition to having called him a "moron" in response to such innuendo.
post #61. Your SECOND post.
No, you ______, pot decriminalization and/or legalization. And I don't use it.
How about your justification for pot's prohibition?
The first mention of legalization was by an opponent, in post #10.
I'm not aware that one has to prevent fertilization to get good tomatoes.
You don't, instead you must encourage it, something that can be difficult in pesticide ridden cities with few bees. However the details might differ, I still suspect the level of difficulty is about the same. One must not only prevent the wrong fertilization, but provide the correct fertilization in order to grow hybrid seed corn. Legions of "Jutes", are used in this endeavor in many areas.
I grew very nice tomatoes this summer, and all I did was plant and fertilize (once).
By which I mean "put down Miracle Gro soil."
What about it?
Your argument is so ridiculous it's tough to ignore.
It took you only 'til your second post to descend.
It's irrelevant in any case, carry on. You had no credibility the moment you made that comment, so all the rest is Nada.
When you are in a hole, it's always a good idea to stop digging.
That's right. Name calling is as irrelevant as are the arguments for legalizing marijuana. Neither are productive.
Depends on what you are trying to produce.
These people were criminally mentally ill. Or are you going to argue that they were, somehow, "sane"? Prohibition was the social vehicle through which they could be violent and the depression the reason that their were too few mental institutions. Actually, mental hospitals are the province of the rich and crazy, violent lifestyles the province of the poor and crazy. World War II put most of the violent men of the 1940's in the army. Right now, the prisons are full of their types who should be in mental hospitals. Permanently.
Actually, I'm trying to prevent future occurrences like the "Stockton School Yard Massacre" and the ensuing gun control that proceeds from societies lack of controlling the mentally ill. The free use of marijuana among the mentally ill does not help the cause of the 2nd. Amendment.
So, to simplify the issue for the attention impaired, its either legalize marijuana and loose the 2nd. Amendment or hospitalize the mentally ill and keep your rights to firearms.
OK you pot heads, take your pick! Your guns or your joints? The crazy and the Democrats won't let you have both.
Can't help yourself can you?
Your guns or your joints?
It's only your opinion that those are the only two choices.
You sure about that Clint?
It's always easy to spot the junk science. They almost always talk about a single aspect of a system and use it as THE defining factor for the study.
Not really. The coincidence of steadily decreasing drug laws and the explosion of gun control is too obvious for the attentive to miss. As drug use goes up, gun violence goes up and increased gun control occurs.
From Patrick Purdy in Stockton, California, to Thomas Hamilton in Dunblane, Scotland, the one common denominator is a long known history of mental illness. That marijuana causes increased psychotic episodes, in the known mentally ill, is also another common precursor to violence.
I'm willing to bet you a $1,000.00 that those who have gone "postal" have used pot, or another illegal drug, or stopped their legal "meds", at least 72 hours before they started shooting people.
The bet thing is a real non starter on-line.
Not to mention the research you have to do to prove your dubious point.
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