Wasn’t there violence in the Kansas area (related to slavery) in about this time that lead to the Missouri Compromise? Forgive me if I have my history backward in this instance.
Yes there was slavery-related violence going on in Kansas from 1855 on. The Missouri Compromise was 1820 and was a major element in the story. The direct cause of the current troubles was the Kansas-Nebraska Act of 1854, which effectively repealed the Missouri Compromise and made Kansas the focal point in the argument of whether slavery could be extended from where it existed in the southern states (including Missouri) to newly created federal territories.
https://en.wikipedia.org/wiki/Bleeding_Kansas
Bleeding Kansas, Bloody Kansas or the Border War was a series of violent political confrontations in the United States involving anti-slavery “Free-Staters” and pro-slavery “Border Ruffian”, or “southern yankees” elements in Kansas between 1854 and 1861, including “Bleeding Congress”. The Kansas–Nebraska Act of 1854 called for “popular sovereignty”—that is, the decision about slavery was to be made by the settlers (rather than outsiders). It would be decided by votes—or more exactly which side had more votes counted by officials. At the heart of the conflict was the question of whether Kansas would allow or outlaw slavery, and thus enter the Union as a slave state or a free state. Pro-slavery forces said every settler had the right to bring his own property, including slaves, into the territory. Anti-slavery “free soil” forces said the rich slaveholders would buy up all the good farmland and work it with black slaves, leaving little or no opportunity for non-slaveholders. As such, Bleeding Kansas was a conflict between anti-slavery forces in the North and pro-slavery forces from the South over the issue of slavery in the United States. The term “Bleeding Kansas” was coined by Republican Horace Greeley, editor of the New York Tribune; its violence indicated that compromise was unlikely, and thus it presaged the Civil War.