Posted on 08/31/2016 1:25:29 PM PDT by Tilted Irish Kilt
A drug called aducanumab might remove the toxic proteins thought to trigger Alzheimer’s disease from the brain, suggests findings from a small clinical trial.
The results, reported on 31 August in Nature1, showed that aducanumab broke up amyloid-β proteins in patients with early-stage Alzheimer’s disease. The trial mainly tested the safety of the drug in people, and so the final word on whether aducanumab works to ameliorate the memory and cognitive losses associated with Alzheimer’s will have to wait until the completion of two larger phase III trials. They are now in progress, and planned to run until at least 2020.
I sure hope this is for real.
What an awful, awful, disease. I have known several people closely who have (had) it, and it is, as you said, evil.
If my wife ever got it, I don’t know what I would do, how I would deal with it. Even thinking about it makes my insides feel completely empty.
My aunt died 2 years from complication due to Alzheimers. She helped raise me growing up.
Wished I knew this drug was available back then.
I noticed that the 2015 article was not specifically dated as to the date of publication. Also, at that time there was only limited evaluation of the drug.
So with 166 American treated here,
and 177 treated in England
do you believe enthusiasm is unwarranted or presumptuous ?
“$600 bucks a pill”
It’s a mouse-antibody drug, so it is injected - I believe once a month.
The trials are huge - and expensive.
I suspect pricing at between $5,000 to $10,000/monthly shot.
Nursing home care probably averages about $9,000/month nationwide.
It will be your tax dollars (via Medicare Part D) getting stuffed into Swiss banks.
Man tells his doctor “Give it to me straight, doc”. The doctor says “Well, I have bad news, you have two very grave conditions. First, you have cancer.” The man drops his head and finally says “Okay doc, I was afraid of that. What else?” The doctor says “You also have alheimers”. The man says “Oh thank God, I was afraid it was cancer!”
“Diabetes is the one I’m waiting for (specifically Type 1). So many studies have come out in the last decade with introducing new islet cells that had amazing success, but they never went further”
Insurers figure it’s better to give you insulin at $4,000/year than to pay for a $50,000 operation. In twelve years you’ll probably be another insurer’s problem.
Now if they could find a busting agent that could do a similar scrubbing job on the plaque in arteries/veins without causing other problems.
“mouse-antibody”
monoclonal antibody
I don't remember.
As an employee of a medical device manufacturer and as the father of a son with type I diabetes, I can tell you twice over that you are an idiot.
“do you believe enthusiasm is unwarranted or presumptuous ?”
There are two major theories about Alzheimer’s, amyloid and tau.
This drug seems to work well on amyloid, at least for a while.
Scientifically, this drug is important.
Medically, hopefully for us and the folks with the sick brains the drug will work for many years, not just say one or two.
Length of response is one big if now.
The second big if is will it clear out the nursing homes by working on really severe cases.
I couldn’t find a trial for my former neighbor’s 92-year old mum in England. She gets TIAs, so she isn’t a good trial candidate for the drug maker. Compassionate use might be an option.
"The results, reported on 31 August in Nature1, showed that aducanumab broke up amyloid-β proteins in patients with early-stage Alzheimer’s disease.
The trial mainly tested the safety of the drug in people, and so the final word on whether aducanumab works to ameliorate the memory and cognitive losses associated with Alzheimer’s
will have to wait until the completion of two larger phase III trials.
They are now in progress, and planned to run until at least 2020.
Please see post #73
.
Keep reading.
Removing the plaque didn’t un-do the Alzheimers.
Blaming the plaque, which is a symptom, not a cause, just gives the druggies more excuses to get richer drugging victims.
.
.
Amyloid plaque is a symptom (assumed, not proven) of Alzheimers.
There is no empirical evidence directly showing it to be a cause.
.
later
great
So you are suggesting that tau is the cause,( as also does the Mayo Clinic).
and that amyloid plaque is the symptom/ side effect/ by-product of Alzheimers ?
Or perhaps some other factor ?
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