A few years ago, I read an article in Hot Rod magazine where some fella shoehorned a short block V-8 into one. He did have to beef-up the chassis, though. :D
Yes, but that would be more of a drag car. Not much fun in the corners with all that weight biased forward...a lot of "pushing".
Now an aluminum Rover (Buick) V-8 would be a different story.