Yes.
I have worked with many people using things like nattokinase.
It is classified as a highly-fibrinolytic (fibrin digesting) enzyme.
Others are: serratiopeptidase/serrapeptase (silkworm), lumbrokinase (earthworm), chymotrypsin (human).
Fibrin is the universal protein in scar tissue and debris in the body. It accumulates with age. In fact, a clinical def8nition of death by natural cause is often fibrosis of the viscera - hardening of the organs, with loss of function. It is a factor in many conditions, such as fibromyalgia and fibroid tumors.
Partially digested proteins that enter the blood stream (via leaky gut) can cause autoimmine reactions.
Circulating immune complexes that become perpetual, leading to chronic inflammation, are also proteins.
Systemic Enzymes - formulas based on one or more highly-fibrinolytic enzyme, are effective at breaking down these various ptoteins in the body.
I generally prefer a nutritional approach to most situations. But systemic enzymes are the most potent and useful non-nutritional (although natural) supplement I have ever found.
They originated in Germany, as Wobenzyme, in 1959.
Although nattokinase is mostly associated with digesting arterial plaque, it has broader applications like the others.
I take Serrapeptase and have for years. I found it while doing research on Hidradenitis Suppurativa. Funny thing is I had just been diagnosed with Prinzmetal Angina and been given nitro since I was having about 4 attacks a month. Sometimes more. Since I have been taking Serrapeptase I have about 1-2 attacks a year.