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Worms to help combat allergies
BBC ^ | 9/5/05 | Jonathan Amos

Posted on 09/05/2005 2:12:29 PM PDT by LibWhacker

Irish scientists are investigating parasitic worms to try to find new ways to prevent asthma and reduce allergies.

Dr Padraic Fallon, from Trinity College Dublin, and colleagues have already managed to cure asthma in lab mice by infecting them with the tiny creatures.

The team now has to explain how the parasites achieve this feat at a molecular level.

If they can do that, they should then be able to synthesise a new drug compound to treat asthma in people.

On the rise

Asthma and other allergies have increased almost threefold over the last 30 years in many developed countries, including Ireland and the UK.

Scientists believe this is because of significant changes in lifestyle, from rural to urban living, and even a reduction in family size may be to blame.

The thinking behind this theory is that people living in modern industrialised societies are no longer exposed to the pathogens, such as viruses and bacteria, they would have been in the past, and so their bodies react to other, more minor threats.

"In Africa, for example, the immune system is too busy chasing after worms to bother going after house dust mites," explained Dr Fallon.

"In a developed society, the immune system is looking for things to respond to.

"It's evolved to see worms and suddenly there are no worms there. So suddenly house mites, peanuts - whatever the allergies are - occupy the immune system and it responds and causes disease," he told BBC News.

In a study in Gabon, Africa, schoolchildren that were infected with worms had lower allergic responses to house dust mites than children with no worms.

When the children had their worms removed by drugs they then developed increased allergic responses.

Red blood cells

The particular worm in question, the schistosome, is the cause of bilharzias, or schistosomiasis.

As the worms feed on red blood cells and dissolved nutrients such as sugars and amino acids, they can cause anaemia and fatigue, and in some cases the victim passes red urine, tinted by blood lost through the damaged kidneys.

It is thought that around 250 million people are infected with bilharzia in the tropics.

Dr Fallon says the worm has clearly evolved a way to control the human immune system, raising and lowering inflammation in its host to just the right level to ensure its parasitic lifestyle can be maintained.

The trick now, he says, is to learn how the worm does this so that the knowledge can be applied to allergic diseases.

"We believe that this research will lead us to develop a new ways of preventing and treating asthma and anaphylaxis, which can then be extended to treat inflammatory bowel disease and arthritis," Dr Fallon said.

TOPICS: Health/Medicine
KEYWORDS: allergies; allergy; asthma; asthmatics; immune; schistosome; system; worms

1 posted on 09/05/2005 2:12:30 PM PDT by LibWhacker
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To: PatrickHenry

Thought you might want to ping the Science List on this one.

2 posted on 09/05/2005 2:15:25 PM PDT by Quark2005 (Where's the science?)
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To: Quark2005; neverdem
I donno. I don't really ping for something that's essentially medical. There's not much here that would interest the evolution list. I think neverdem has a health ping list.
3 posted on 09/05/2005 2:26:00 PM PDT by PatrickHenry (Discoveries attributable to the scientific method -- 500 billion; to creation science -- zero.)
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To: LibWhacker

Just give me my inhaler please.

4 posted on 09/05/2005 3:08:33 PM PDT by SouthernFreebird
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To: Lil'freeper


5 posted on 09/05/2005 3:28:13 PM PDT by big'ol_freeper ("Freedom consists not in doing what we like, but in having the right to do what we ought." Pope JPII)
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To: LibWhacker

Hmmm. I suffer from hideous migraines. Unless I have a cold. As soon as I get over the cold, headaches come right back.

6 posted on 09/05/2005 3:41:17 PM PDT by oprahstheantichrist (...or false prophet at the very least.)
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To: blam; Cindy

Bizarre ping!

7 posted on 09/05/2005 7:35:08 PM PDT by Domestic Church (AMDG...)
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To: LibWhacker

The hygiene hypothesis.

8 posted on 09/15/2005 1:42:25 AM PDT by Jeff Chandler (Peace Begins in the Womb)
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