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Local Physician: HIV/AIDS Cure Getting Little Publicity
Baldwin County Now ^ | Bob Morgan

Posted on 09/03/2009 10:12:21 AM PDT by nickcarraway

A Foley physician said what appears to be the first case of HIV/AIDS cure in the world is getting little mention in the media.

Dr. Awadhesh K. Gupta, medical director at Foley Walk-In Med Care, said he first heard of the medical breakthrough in April when he attended the Annual Conference of the American College of Physicians in Internal Medicine in Philadelphia.

It’s a conference Gupta tries to attend every year.

“This is the most prestigious organization of physicians in Internal Medicine and is responsible for certifying post graduate training in Internal Medicine. It is also one of the oldest,” he said.

According to Gupta, who has been practicing medicine in the South Baldwin area since 1997, the cure was first reported in early 2008 by a group of physicians from Germany at the annual conference on “Retroviruses and Opportunistic Infections” in Boston. The New England Journal of Medicine, one of the most prestigious medical journals in the world, finally published the report in its Feb. 12, 2009, issue, Gupta said.

So why has the news of the first case of HIV/AIDS cure received so little attention where the public is concerned?

“I can’t be sure as to why so little publicity,” Gupta said recently.

“My guess is that most scientific researchers are somewhat stunned that a clinician — not a research scientist — has been able to come up with the cure. Most of the big research money and big name American institutions are somewhat embarrassed to acknowledge that the very first case of HIV cure is not coming from their institutions.”

The cure, instead, is coming from Charity University Hospital in Berlin, Germany, and the doctor is Gero Huetter, who works in the Department of Hematology, Oncology and Transfusion Medicine at the same hospital.

Asked about the reaction of attendees at the medical conference in Philadelphia as regarded the news of an HIV/AIDS cure, Gupta said, “Unfortunately, because of the hectic schedule, I did not try to engage too many physicians. However, the doctor presenting this information seemed extremely excited about it.”

AN AMERICAN

WORKING IN BERLIN

As Gupta explains the case and cure in question, a 40-year-old American working in Berlin had been HIV-positive for 10 years. The patient’s HIV infection had been under control for four years with “conventional HAART treatment regimen” (Highly Active Anti-Retroviral Therapy).

When the patient developed leukemia, however, a bone marrow transplant of stem cells was done using standard protocol, which Gupta said includes radiation therapy and chemotherapy prior to the transplant.

“Remember, once you stop HIV drugs, the HIV viral count rises very rapidly, usually within a few days to a week,” Gupta said.

According to Gupta, Huetter, the German physician treating the American, deliberately chose a stem cell donor who had a gene mutation known as “CCR-5 Delta- 32,” rather than using the best matched donor.

Gupta said Huetter remembered research first observed in 1996 - research Gupta said is well known in the scientific community. That research found that certain gay men in the San Francisco area remained uninfected with HIV in spite of engaging in risky sexual activities. As it was later discovered, those men had the CCR-5 Delta-32 gene mutation.

As it turned out, the patient’s stem cell transplant was a success, Gupta said, even though the patient had to have a second stem cell transplant (from the same donor) when his leukemia relapsed.

“This patient has been off all his HIV drugs for two years now,” Gupta said. “He continues to show no detectable signs of HIV in all the known places HIV is detected — no signs of HIV in his blood, bone marrow, lymph nodes, intestines or brain.” Also, the patient’s T-cell count remains normal.

Thus, according to Gupta, within the limits of scientists’ ability to detect HIV, it appears this patient’s HIV has been “eradicated.”

CCR-5 DELTA-32

The gene mutation CCR-5 Delta-32 is found mostly in white European populations, especially northern Europeans and Scandanavians, according to Gupta, who is on the staff of South Baldwin Regional Medical Center and served as chief of medicine in 2008.

“Those who have this gene mutation from both parents are completely resistant to most common forms of HIV infection. You can get tested for it if you wish,” he said.

“It is believed that this genetic mutation may have happened during long periods of small pox, plague and other pandemics that devastated European populations.”

While the “American living in Berlin” case is in Gupta’s words the “first case of confirmed cure of HIV in the world,” he cites a 1989 case that is similar. Dr. John Rossi, currently at City of Hope Cancer Center in Durate, Calif., had a 41-year-old patient with AIDS and lymphoma. The patient underwent radiation and drug therapy in removing his bone marrow and receiving new cells from a donor.

Whether the donor had the CCR-5 Delta-32 gene mutation or not is not known, Gupta said, but when the patient died of his cancer at age 47 autopsy tests from eight organs and the tumor revealed no HIV.

“I have no doubts that present day high tech stem cell transplantation from CCR-5 Delta-32 donors can cure HIV,” Gupta said, noting, at the same time, that the procedure is expensive at present and has significant risks of complications and a high mortality related to the procedure itself.


TOPICS: Business/Economy; Health/Medicine; Local News
KEYWORDS: aids; aidscure; ccr5delta32; hiv; medicine; stemcells

1 posted on 09/03/2009 10:12:21 AM PDT by nickcarraway
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To: nickcarraway

Maybe the very small number of people with the immunity gene simply don’t want to become donors ~


2 posted on 09/03/2009 10:15:41 AM PDT by muawiyah
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To: nickcarraway

A cure means lots of funding will be drying up.....


3 posted on 09/03/2009 10:21:45 AM PDT by Always Right
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To: nickcarraway
Gupta said Huetter remembered research first observed in 1996 - research Gupta said is well known in the scientific community. That research found that certain gay men in the San Francisco area remained uninfected with HIV in spite of engaging in risky sexual activities. As it was later discovered, those men had the CCR-5 Delta-32 gene mutation.

Could they still be carriers?

4 posted on 09/03/2009 10:26:50 AM PDT by a fool in paradise (Kennedycare?Recall that "Animal Farm" begins with a Socialist Revolution to honor Big Major's legacy)
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To: muawiyah

Or fear that they MUST become donors...


5 posted on 09/03/2009 10:31:34 AM PDT by frithguild (Can I drill your head now?)
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To: Always Right

This is incredible. I haven’t heard of this at all and I agree with you, these parasites in research don’t want a cure they just want their (our) money. Absolutely incredible but not surprising. Just wow.


6 posted on 09/03/2009 10:32:25 AM PDT by SaintDismas
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To: a fool in paradise
Could they still be carriers?

It does not seem so - there is no sign of infecion anywhere in their bodies. Their immune systems kill the virus.

7 posted on 09/03/2009 10:33:08 AM PDT by frithguild (Can I drill your head now?)
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To: nickcarraway

couldnt this be synthesized in a lab?


8 posted on 09/03/2009 10:36:11 AM PDT by thefactor (yes, as a matter of fact, i DID only read the excerpt)
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To: SaintDismas

BINGO! Now the propaganda for more $$$$$$$$$ to tug at our wallets will be gone. On the other hand, it’s a free for all for the gays to go animal on each other with no consequence.


9 posted on 09/03/2009 10:38:31 AM PDT by max americana (i)
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To: max americana

They are not restrained by anything already my friend I’m afraid. Their life expectancy as a group is so skewed regardless of the “protection” that can supposedly be obtained through wearing a condom. Seems I remember reading that the AIDS virus is pretty tiny and able to get through the material.

Anyway, this silence is so appalling I’m still stupified. The liberals in this world are so evil, even their pet group the gays are being betrayed here. Unbelievable.


10 posted on 09/03/2009 10:43:42 AM PDT by SaintDismas
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To: muawiyah

It’s more likely they’re just not aware of it.

This is just another reason for me to not trust the MSM.


11 posted on 09/03/2009 10:56:13 AM PDT by jlaughlin
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To: SaintDismas
I can think of a few reasons that it has not made the general press. It must be extremely expensive and very dangerous. I suspect they do not want to cause a land rush by people that are infected. Can't you imagine the confusion that would result from 100 thousand homosexuals demanding that the government finance their cure.
12 posted on 09/03/2009 11:14:00 AM PDT by ANGGAPO (Leyte Gulf Beach Club)
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To: ANGGAPO

Well that may be true, but it doesn’t excuse the silence here. People have been screaming loudly for a cure and consequently as we all know, there goes the money, and the most of money spent on research for disease goes guess where. Even though it’s not the major killer disease here in America it just doesn’t matter. All that money those researchers now don’t need could be redirected to all those unfortunate individuals that have the AIDS virus?

Follow the money, it’s all that counts. Evil, pure evil.


13 posted on 09/03/2009 11:32:49 AM PDT by SaintDismas
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To: max americana
One additional factor: the bone marrow transplant recipient must be a close-enough tissue match to the Northern European donor to not reject the transplant.

Perhaps a cure that only cures Northern Europeans is annoying to some?

14 posted on 09/03/2009 11:39:23 AM PDT by PapaBear3625 (Public healthcare looks like it will work as well as public housing did.)
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To: jlaughlin

“It’s more likely they’re just not aware of it.”

Scientists are required to be familiar with the literature in their field. Why? Because that is part of their job description.


15 posted on 09/03/2009 12:21:28 PM PDT by GladesGuru (In a society predicated upon freedom, it is essential to examine principles,)
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To: nickcarraway
The gene mutation CCR-5 Delta-32 is found mostly in white European populations, especially northern Europeans and Scandanavians, according to Gupta,

That's racist!

16 posted on 09/03/2009 12:52:17 PM PDT by The Comedian
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To: The Comedian

Some interesting information here:

http://www.lexiline.com/lexiline/lexi76.htm

(I do not know the veracity of this source.)

DG


17 posted on 09/03/2009 2:14:54 PM PDT by DoorGunner ("...and so, all Israel will be saved")
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To: PapaBear3625

that was a good point. Thanks. The same European transplant angle was also used on a CSI episode when the newby CSI was found to be of Norwegian descent.


18 posted on 09/04/2009 2:45:31 PM PDT by max americana (i)
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To: All
Maybe the very small number of people with the immunity gene simply don’t want to become donors ~


The problem is a different one. An ideal HIV patient (no STDs or promiscuous sex, no drug use, no hepatitis etc., high level of compliance with the therapy) can expect to live a (n almost) normal life span. The side effects of antiretroviral therapy (risk of diabetes, heart attack etc.) have to be weighed against the risks of this cure.

A bone marrow transplant itself is very risky, because you have to destroy the old immune system to a degree where the transplant will eliminate the rest. And even afterswards immunosuppression against GVHD (graft-vs.-host-disease) is the norm. Immunosupressants themselves are potent drugs, with a number of side-effects of their own.

So if the "cure" means that you replace a working HAART regimen with potentially problematic immunosupressive regimen, it's not always worth it. It's worth looking into it, but far from a panacea.
19 posted on 10/04/2009 9:57:25 AM PDT by wolf78 (Inflation is a form of taxation, too. Cranky Libertarian - equal opportunity offender.)
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