Posted on 11/12/2010 9:03:42 PM PST by SunkenCiv
I want to thank you for your detailed responses to this idea. Although I did study biological sciences, and worked as a lab tech in medical schools and at NIH, I did many years of other things. So now at 72 it feels a little unreal to think I could actually do something significant with this, so the encouragement is much appreciated. Now I will answer the specific points you raised. This will also help clarify my thinking.
First of all my theory is that there is at least a partial genetic basis for Alzheimers. Scientists have discovered some genes which they believe correlate with the occurance of Alzheimers (like they now identify breast cancer genes). My hypothesis is that, based on the detailed observation and care of my husband, such a gene may cause wandering bahavior that would benefit surviving blood relatives because there would be more available food, especially in winter or drought conditions. Thus the offspring bearing this gene would tend to pass it on and on. This behavior seemed to occur at a time when mobility and potential usefulness was coming to an end, but before real helplessness set in. This would be an optimum time in a primative setting for the person to cause their own death.
Secondly, in the realm of sociology, I have found that it is possible to set up conditions that make it possible for someone with Alzheimers to be a contributing member of the “tribe” past the time I have heard/read that most believe it is possible or practical. When my husband first became “difficult” and I looked into an insitutional placement, I was told it was over $50,000 a year and could go on for as much as 10 years. I ended up caring for him with minimal help and he died at home. Only the last 6 months was physically very hard as his body began to deteriorate rather rapidly. Fortunately, I was ten years younger, in good health, and physically strong.
1) I have made a great many other observations besides the ones I have mentioned here and have already written a lot of them down.
2) The additional research I have done was to look at aging research data from long settled relative urbanized areas in India and West Africa, and black people in Cleveland. I should do a lot more of this. Also, I would need to talk with others who have cared for Alz. people, especially in a family (tribal) setting to see if their observations tend to confirm mine.
3) I have outlined my hypotheses above. Need to think more about this whole issue.
4) Testing would involve much larger studies that I am not in a position to do. However, if I could interest professionals, I could certainly suggest some practical parameters for conducting some aspects. This might include genetic testing, familial observations and record keeping, more detailed studies on aging in homogenious populations from long settled well populated areas vs. the same on thin widely scattered populations like Laplander, Inuit, Kalahari Bushmen, etc.
5) Reporting findings could occur in several ways. I have already thought of writing something for the AARP magazine about my experience caring for my husband, including my observations and theory generated by caring for him. If not AARP, some other popular journal or blog dealing with aging, Alzheimers and dying. Where that might lead, who knows?
Regarding posting on FR, I wish they would not call original contributions “vanities”. Certainly some of the posts are, but I would call others “original observations” or “original writing”. At any rate, thank you again for your suggestions, and any others you may be inspired to add. Last thought re PhDs. BS = Bull Sxxx, MS = More of Same, PhD = Piled higher and Deeper. ;-)
I think that it was determined that in olden time if one survived to age 5, one might live to a ripe old age. My husband’s people were poor farmers in southern Illinois. In the mid 1800’s, one ancestor had 9 children. Five died at the age of 2 in August or September. This was probably the result of weaning and bad sanitation in the hot summer.
I once got an old book which described famous Greeks and Romans 2000 or more years ago. I was amazed to see that the average age of death for the famous Greeks was around 70, but the average age of death for the famous Romans was around 50, and this was after I removed Romans who died of military activity. I think the Greeks had a much healthier life style, diet and enviroment, including no lead in their pipes, if they had pipes.
I’ve looked at my family tree, too. It seems that practically all of my ancestors had large families. You are correct about children. Many, many children never made it past their 5th birthday and barring accidents and wars, if you made it past that magical 5th birthday, you had a decent chance of living to a ripe old age.
I’ve looked at my family tree, too. It seems that practically all of my ancestors had large families. You are correct about children. Many, many children never made it past their 5th birthday and barring accidents and wars, if you made it past that magical 5th birthday, you had a decent chance of living to a ripe old age.
P.S. the “average life expectancy” of 40 years back in the 1800s included a LOT of small children to bring the average way down.
The Neanderthal theory of autism, Asperger and ADHD
Long-living famous Greeks had their needs met by people who died young slaving away, and that was true for the Romans as well. Augustus ruled for 50 years or so, and his immediate successor lived a long life, as did the fourth emperor, Claudius. Caligula (number three) was assassinated, and Nero (number five) committed suicide when he heard the coup d’etat group was nearing. There really wasn’t much difference in their diet and environment. The lead pipe thing is basically a myth — they had the lead pipes, but it didn’t do much to them, because the water systems the Romans used ran all the time (they didn’t use valves for home plumbing), and like the Greeks, the Romans drank wine more than water. :’)
Good job. So you would view it as a useful gene. Is it dominant or recessive? You’d also want to measure the onset of this “wandering off” behavior. Is it consistent across Alzheimer sufferers as you postulate? That would go a long way toward supporting your theory.
I would formalize your ideas and try to correspond with univeristy scientists studying Alzheimers as a genetic issue or sociologists trying to help manage the disease for caregivers like you’ve been.
I’d love to read more about how you managed with your husband. It is the practical that often leads to the scientific insight. AARP would be a great way to get the information out and your observations are worthy of that.
Please keep me posted and FReepmail me if you rather not discuss this in public.
I’d just get started doing it today. Why wait?
Thank you for your encouragement. I may start printing up the several thousand words I have already written longhand, and I could forward them to you if you are interested. I don’t think it would be prosurvival under present circumstances. In fact, I think there will be a tremendous waste of resources until medicine finds a way to delay the onset of the severe phases of the disease. Also society can find better ways of getting some useful activity from early Alzheimers people as I did when I had him help me build a cabin.
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