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Red wine: Exercise in a bottle?
Federation of American Societies for Experimental Biology ^ | 30-Jun-2011 | Gerald Weissmann, M.D.

Posted on 06/30/2011 10:15:18 AM PDT by Pharmboy

New research in the FASEB Journal suggests that a daily intake of resveratrol prevents the ill effects of simulated weightlessness on muscle and bone metabolism Bethesda, MD—As strange as it sounds, a new research study published in the FASEB Journal (http://www.fasebj.org), suggests that the "healthy" ingredient in red wine, resveratrol, may prevent the negative effects that spaceflight and sedentary lifestyles have on people. The report describes experiments in rats that simulated the weightlessness of spaceflight, during which the group fed resveratrol did not develop insulin resistance or a loss of bone mineral density, as did those who were not fed resveratrol.

According to Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "There are overwhelming data showing that the human body needs physical activity, but for some of us, getting that activity isn't easy. A low gravity environment makes it nearly impossible for astronauts. For the earthbound, barriers to physical activity are equally challenging, whether they be disease, injury, or a desk job. Resveratrol may not be a substitute for exercise, but it could slow deterioration until someone can get moving again."

Scientists studied rats that underwent simulated weightlessness by hindlimb tail suspension and were given a daily oral load of resveratrol. The control group showed a decrease in soleus muscle mass and strength, the development of insulin resistance, and a loss of bone mineral density and resistance to breakage. The group receiving resveratrol showed none of these complications. Study results further demonstrated some of the underlying mechanisms by which resveratrol acts to prevent the wasting adaptations to disuse-induced mechanical unloading. This study also suggests that resveratrol may be able to prevent the deleterious consequences of sedentary behaviors in humans.

"If resveratrol supplements are not your cup of tea," Weissmann added, "then there's good news. You can find it naturally in red wine, making it the toast of the Milky Way."


TOPICS: Health/Medicine
KEYWORDS: faseb; oenology; redwine; resveratrol; wine
Just a cautionary note: resveratrol is very poorly absorbed, so supplements do not get the blood levels up very much, and neither does red wine. The pharmaceutical industry has been working on molecular forms which are more readily absorbable.
1 posted on 06/30/2011 10:15:23 AM PDT by Pharmboy
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To: neverdem; thefactor; SunkenCiv; Dr. Scarpetta; aculeus
Ping

I like Glenlivet myself...

2 posted on 06/30/2011 10:17:49 AM PDT by Pharmboy (What always made the state a hell has been that man tried to make it heaven-Hoelderlin)
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To: Pharmboy
Amen brother. Single malt is the only way to fly.


3 posted on 06/30/2011 10:20:49 AM PDT by Lazlo in PA (Now living in a newly minted Red State.)
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To: Pharmboy; derllak
So, does this mean we have to drink a whole lot of it to absorb the good stuff?

:-)

4 posted on 06/30/2011 10:21:34 AM PDT by Lakeshark (Thank a member of the US armed forces for their sacrifice)
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To: Pharmboy

Beer has done a good job of keeping me from suffering from weightlesness


5 posted on 06/30/2011 10:22:09 AM PDT by CrazyIvan (Obama's birth certificate was found stapled to Soros's receipt.)
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To: Pharmboy

Think I’ll go drink me a marathon.


6 posted on 06/30/2011 10:22:30 AM PDT by dfwgator
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To: Pharmboy
Sheeesh...poor cold water on good news (which we get little enough of these days as it is).

Just go with it, man...after a bit you won't even care about absorption. ;-)

7 posted on 06/30/2011 10:24:04 AM PDT by Scott from the Left Coast
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To: Lakeshark

I’ll drink to that!

I’m hoping cheetos will have the same effect.


8 posted on 06/30/2011 10:25:37 AM PDT by derllak
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To: Pharmboy

Red wine is more like ‘headache in a bottle’ for me. Migraine city.


9 posted on 06/30/2011 10:25:54 AM PDT by The Iceman Cometh (I'm called a 'teabagger'? Well, get over here liberal and I'll show you what that means.)
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To: derllak
Pita chips have that affect.

They listen well too........

10 posted on 06/30/2011 10:27:13 AM PDT by Lakeshark (Thank a member of the US armed forces for their sacrifice)
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To: All

b


11 posted on 06/30/2011 10:28:01 AM PDT by Maverick68
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To: Lakeshark

Lol!

Talking to your pita chips probably means you’ve had enough. :P


12 posted on 06/30/2011 10:30:55 AM PDT by derllak
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To: Pharmboy

And one, and two, and three...

13 posted on 06/30/2011 10:31:05 AM PDT by stormer
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To: derllak

Likewise, talking to your bottle of red wine.....


14 posted on 06/30/2011 10:32:20 AM PDT by Lakeshark (Thank a member of the US armed forces for their sacrifice)
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To: All

Ha! Some great ones, folks...chuckling at office.


15 posted on 06/30/2011 10:36:10 AM PDT by Pharmboy (What always made the state a hell has been that man tried to make it heaven-Hoelderlin)
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To: The Iceman Cometh
Indeed...not a rare phenomenon at all (my wife has this, but reds don't bother me when I do drink them). Try this site for some answers.
16 posted on 06/30/2011 10:39:29 AM PDT by Pharmboy (What always made the state a hell has been that man tried to make it heaven-Hoelderlin)
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To: Pharmboy

So I guess when I tell people that I’m spending all weekend at the gym I won’t REALLY be lieing.


17 posted on 06/30/2011 10:42:21 AM PDT by thefactor (yes, as a matter of fact, i DID only read the excerpt)
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To: The Iceman Cometh

“Migraine City”

Me too! Even a half a glass gives me a migraine.


18 posted on 06/30/2011 10:43:04 AM PDT by momtothree
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To: Pharmboy

If the wine does not deliver enough resveratrol to increase blood levels, then what is the explanation for the apparent positive clinical effects red wine has in humans?


19 posted on 06/30/2011 10:48:44 AM PDT by ottbmare (off-the-track Thoroughbred mare)
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To: Pharmboy; Lazlo in PA
BTW, here's an article about Glenmorangie's new offering. It's a single malt that was made in 1981 and aged for almost 29 years. It's called 'Pride' and it costs $3,600 a bottle. Only 1,000 bottles produced. Crystal bottle, wooden case, etc...

http://www.cigaraficionado.com/webfeatures/show/id/15916

20 posted on 06/30/2011 10:49:04 AM PDT by thefactor (yes, as a matter of fact, i DID only read the excerpt)
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To: derllak; Lakeshark
Talking to your pita chips probably means you’ve had enough. :P

Naw, it's only when they start talking to you that you've had enough.

21 posted on 06/30/2011 11:01:20 AM PDT by Hoffer Rand (There ARE two Americas: "God's children" and the tax payers)
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To: ottbmare
Big mystery...one explanation is that the health effects are due to the alcohol and not the wine. For example, even the USDA's dietary guide for Americans says alcohol (in moderation) is good for you. Click here and start reading at the bottom of p. 29. When they give very high levels to mice and rats of resveratrol good things happen for sure, but our levels don't get up nearly that high.
22 posted on 06/30/2011 11:03:36 AM PDT by Pharmboy (What always made the state a hell has been that man tried to make it heaven-Hoelderlin)
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To: Pharmboy

In complete seriousness I would suggest they’re looking at this in exactly the wrong way. Exercise is red wine without the bottle - same conclusion just turned around.


23 posted on 06/30/2011 11:05:22 AM PDT by 2 Kool 2 Be 4-Gotten (Welcome to the USA - where every day is Backwards Day!)
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To: thefactor
Wow. That looks cool. I would like to just have the bottle to put $60 scotch in.


24 posted on 06/30/2011 11:05:22 AM PDT by Lazlo in PA (Now living in a newly minted Red State.)
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To: Hoffer Rand; derllak
It's when they (Pita chips) start looking like Wonder Woman, then you know you're in trouble......
25 posted on 06/30/2011 11:06:51 AM PDT by Lakeshark (Thank a member of the US armed forces for their sacrifice)
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To: Hoffer Rand; Lakeshark

Looks like we need to do an emergency intervention on Lameshark, Hoffer.

I’ll tie him up and you grab the bottle. :)


26 posted on 06/30/2011 11:11:00 AM PDT by derllak
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To: Big Giant Head

This is an exercise plan I can live with... ;)


27 posted on 06/30/2011 11:11:29 AM PDT by Marie Antoinette (Proud Clinton-hater since 1998.)
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To: derllak; Hoffer Rand
Take the bottle if you must.

Just don't take my Pita chips.....

They're hot.

28 posted on 06/30/2011 11:14:04 AM PDT by Lakeshark (Thank a member of the US armed forces for their sacrifice)
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To: Lazlo in PA; thefactor
Almost too purty to drink (I said almost)
29 posted on 06/30/2011 11:20:59 AM PDT by Pharmboy (What always made the state a hell has been that man tried to make it heaven-Hoelderlin)
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To: Pharmboy
may prevent the negative effects that spaceflight

Okay, that's what I've been looking for to get rid of those post-spaceflight blahs.
I'm telling you, that 52-mile commute to Parsippany in the old days is nothing compared to the 26,200 miles these days . . .

30 posted on 06/30/2011 11:29:37 AM PDT by Tanniker Smith (I didn't know she was a liberal when I married her.)
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To: Pharmboy

BTTT!


31 posted on 06/30/2011 11:40:26 AM PDT by Dr. Scarpetta
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To: Pharmboy
"Resveratrol may not be a substitute for exercise, but it could slow deterioration until someone can get moving again." Oh thank you so much ... I can always use another reason to open a nice bottle of Merlot to sip on for three or four days. At my age 'you have to take your medicine' is one of the best excuses around, even if I don't take any kind of prescription meds. [Now, which brand will I select for medicating tonight?]
32 posted on 06/30/2011 11:45:12 AM PDT by MHGinTN (Some, believing they can't be deceived, it's nigh impossible to convince them when they're deceived.)
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