Fish oil may hold key to leukemia cure (compound produced from fish oil)

Penn State ^ | December 22, 2011

[decimon]

A compound produced from fish oil that appears to target leukemia stem cells could lead to a cure for the disease, according to Penn State researchers. The compound -- delta-12-protaglandin J3, or D12-PGJ3 -- targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice, said Sandeep Prabhu, associate professor of immunology and molecular toxicology in the Department of Veterinary and Medical Sciences. The compound is produced from EPA -- Eicosapentaenoic Acid -- an Omega-3 fatty acid found in fish and in fish oil, he said.

"Research in the past on fatty acids has shown the health benefits of fatty acids on cardiovascular system and brain development, particularly in infants, but we have shown that some metabolites of Omega-3 have the ability to selectively kill the leukemia-causing stem cells in mice," said Prabhu. "The important thing is that the mice were completely cured of leukemia with no relapse."

The researchers, who released their findings in the current issue of Blood, said the compound kills cancer-causing stem cells in the mice's spleen and bone marrow. Specifically, it activates a gene -- p53 -- in the leukemia stem cell that programs the cell's own death. "p53 is a tumor suppressor genethat regulates the response to DNA damage and maintains genomic stability," Prabhu said.

[decimon]

Ping

[mia]

Excellent! Now I know of another benefit from ingesting those big pills every day.

[righttackle44]

I have asked God to make it so. So many need a cure soon.

[cripplecreek]

My dogs and I take fish oil every day.

[djf]

When my dog was about 12 he started to get a bit stiffer and had dry patches on his skin.

I started giving him fish oil, Vit C, and z bit of zinc.
Cleared up his skin good. He made it til he was 16.

[grey_whiskers]

Thanks *very* much for this.

Regular fish-oil dude here.

Cheers!