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Poliovirus kills area college student's brain tumor
WCNC ^ | April 25, 2014 | MICHELLE BOUDIN

Posted on 04/29/2014 6:01:28 PM PDT by Gamecock

SPARTANBURG, S.C. -- It is an incredible story of a girl with a rare and deadly form of cancer seemingly saved by a shocking experimental treatment at Duke Medical Center.

Don't let her easy disposition fool you. She smiles a lot, laughs easily. But doctors will tell you Stephanie Lipscomb should be dead right now.

“The odds weren’t good. They didn’t expect me to live more than two years I don’t think.”

The University of South Carolina nursing student was just 20, a sorority girl, part time waitress, and all around girl next door when she began having migraines.

She was diagnosed with a rare and deadly stage four Glioblastoma, a brain tumor the size of a tennis ball.

“It was shocking, scary, mind-blowing. I mean I was 20. It’s not very common to have cancer, especially in your head, at 20.”

Doctors were aggressive. They had to be.

“I had surgery. I went through 10 weeks of radiation therapy. I had oral and IV chemotherapy going at the same time as radiation,” Stephanie says.

But just a few months later, the cancer was back. Stephanie got the news at Duke Medical Center's world renowned Robert Tisch Brain Tumor Center.

“They gave me and my mom some time alone in the room, and of course we cried and held each other and hugged. And then my doctor came back in and she was like, ‘Stephanie, we have a couple of options.’”

One was a shocking, experimental study.

“She told me, ‘This has not been tested on humans yet. You would be the first human to ever receive this.’ As soon as she said it, she was like, ‘We’re going inject polio into your brain.’ I was like okay, let’s do it!”

In May 2012, doctors at Duke injected a modified version of the polio virus into the tumor in Stephanie's brain. A researcher there spent 20 years figuring out the virus would attach to the bad cells -- and kill them -- without harming Stephanie in any way.

“Looking back, I’m like oh my gosh, I cannot believe I agreed to do that so quickly. And like I’ve told other people before, I knew that was God.”

Incredibly, last July doctors told Stephanie her tumor was gone.

Her MRI from this January shows only scar tissue remains.

Her story is featured in this week’s People magazine.

Stephanie is cancer free as she gets ready to celebrate the 23rd birthday doctors said she'd never see.

This is still in the experimental stages. A handful of other patients are now involved. The hope is that this same treatment can someday be used to fight other cancers as well.

Stephanie is headed back to Duke this summer to work as a nursing assistant.


TOPICS: Health/Medicine
KEYWORDS: braintumor; glioblastoma; polio; poliovirus; stephanielipscomb

1 posted on 04/29/2014 6:01:28 PM PDT by Gamecock
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To: upchuck

Good news from SC.


2 posted on 04/29/2014 6:02:08 PM PDT by Gamecock (The covenant is a stunning blend of law and love. (TK))
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To: Gamecock

Incredible.


3 posted on 04/29/2014 6:09:55 PM PDT by headstamp 2 (What would Scooby do?)
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To: headstamp 2

Ain’t it though?


4 posted on 04/29/2014 6:10:35 PM PDT by Gamecock (The covenant is a stunning blend of law and love. (TK))
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To: Gamecock
Duke is in Durham, NC. But I guess this is especially good news for some folks SC.
5 posted on 04/29/2014 6:11:49 PM PDT by beef (Who Killed Kennewick Man?)
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To: Smokin' Joe

Ping list worthy?


6 posted on 04/29/2014 6:12:36 PM PDT by Gamecock (The covenant is a stunning blend of law and love. (TK))
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To: beef
The University of South Carolina nursing student who is from South Carolina....
7 posted on 04/29/2014 6:13:55 PM PDT by Gamecock (The covenant is a stunning blend of law and love. (TK))
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To: Gamecock

Thanks for posting….I’m from both Carolinas in a way, and I loved the story.


8 posted on 04/29/2014 6:18:59 PM PDT by C. Edmund Wright (Tokyo Rove is more than a name, it's a GREAT WEBSITE)
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To: headstamp 2

Who wakes up in the morning and thinks, “You know, if I modify that polio virus, I bet I can get it to kill cancer cells!!!”


9 posted on 04/29/2014 6:31:37 PM PDT by DannyTN
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To: DannyTN
I have seen a lot of potential miracle cures for cancer come and go. It stands to reason that some day one of them will work well and for a lot of different cancers. Maybe this is the one.
10 posted on 04/29/2014 6:37:44 PM PDT by beef (Who Killed Kennewick Man?)
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To: DannyTN

A genius!


11 posted on 04/29/2014 6:41:22 PM PDT by Gamecock (The covenant is a stunning blend of law and love. (TK))
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To: DannyTN

Yep, it’s called innovation and I hate to think what ObamaCare is going to ultimately do to things like this.


12 posted on 04/29/2014 6:48:48 PM PDT by headstamp 2 (What would Scooby do?)
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To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...

Ping! (Thanks, Gamecock!)


13 posted on 04/29/2014 6:50:55 PM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing.)
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To: Gamecock

I have lost a beloved niece, my cousins husband, and a long time friend to glioblastomas. This is fantastic news because a glioblastoma is a death sentence.


14 posted on 04/29/2014 6:52:08 PM PDT by Toespi
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To: Smokin' Joe

Thanks for the ping!


15 posted on 04/29/2014 6:52:18 PM PDT by Alamo-Girl
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To: Gamecock

This is fabulous, thank you for posting!


16 posted on 04/29/2014 7:01:45 PM PDT by machogirl (First they came for my tagline)
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To: Gamecock

bkmk


17 posted on 04/29/2014 7:02:30 PM PDT by Sergio (An object at rest cannot be stopped! - The Evil Midnight Bomber What Bombs at Midnight)
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To: Smokin' Joe

Thanks for the ping! This is great news!


18 posted on 04/29/2014 7:03:02 PM PDT by machogirl (First they came for my tagline)
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To: Toespi

Was...


19 posted on 04/29/2014 7:04:15 PM PDT by null and void ( They don't think think they are above the law. They think they are the law.)
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To: DannyTN

I contracted polio at age two (1947). It attacks the myelin sheath tissue around nerves. If the tissue in the blastoma is likened to the myelin sheath then it stands to reason it would attack that. I wonder, the girl’s age is such that she was vaccinated for polio, so the virus would not work against her tissues; but the cancer blastoma is not her tissue!


20 posted on 04/29/2014 7:06:39 PM PDT by MHGinTN
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To: MHGinTN

The tumor is her tissue. Mutated and reproducing out of control, but still hers.


21 posted on 04/29/2014 7:08:32 PM PDT by RegulatorCountry
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To: RegulatorCountry

But the mutation does not enjoy the anti=polio effect from the vaccinations, so is it really here tissue?


22 posted on 04/29/2014 7:15:13 PM PDT by MHGinTN
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To: MHGinTN

That’s what I was thinking.

I guess it took 20 years to figure out how to give it some degree of specificity.


23 posted on 04/29/2014 7:17:47 PM PDT by Gamecock (The covenant is a stunning blend of law and love. (TK))
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To: MHGinTN

Well, how would someone else’s glioblastoma get in there? It was her tissue. No idea how or why the poliovirus didn’t attack healthy tissue.


24 posted on 04/29/2014 7:18:37 PM PDT by RegulatorCountry
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To: Gamecock

Astonishing.

.


25 posted on 04/29/2014 7:19:02 PM PDT by Mears
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To: DannyTN

Polio attacks the healthy CNS tissue so a modified virus that attacks only mutant tissue isn’t that far fetched.


26 posted on 04/29/2014 7:23:34 PM PDT by central_va (I won't be reconstructed and I do not give a damn.)
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To: headstamp 2

Absolutely wild idea - and I think I see why this would work.


27 posted on 04/29/2014 7:25:26 PM PDT by The Antiyuppie ("When small men cast long shadows, then it is very late in the day.")
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To: RegulatorCountry

Vaccinations work by hyping the immune system to attack the thing introduced by vaccination. Since the glioblastoma is in the brain, would the blood brain barrier be holding the immune system back from attacking the polio virus in the brain?


28 posted on 04/29/2014 7:28:08 PM PDT by MHGinTN
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To: RegulatorCountry
No idea how or why the poliovirus didn’t attack healthy tissue.

The virus is genetically engineered. Not only does it kill the tumor cells, but is causes the patient's immune system to attack the tumor cells also.

29 posted on 04/29/2014 7:37:42 PM PDT by Moonman62 (The US has become a government with a country, rather than a country with a government.)
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To: MHGinTN

Being vaccinated would mean she produces antibodies to fight the virus. But if you inject the virus directly into the body, you’re asking for a fight, and some healthy tissues would be damaged in the process.

My guess is that the modified virus didn’t attack healthy cells at all. And either she wasn’t vaccinated or the antibodies didn’t recognize the modified virus.


30 posted on 04/29/2014 7:57:59 PM PDT by DannyTN
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To: AdmSmith; AnonymousConservative; Berosus; bigheadfred; Bockscar; cardinal4; ColdOne; ...

Thanks Gamecock.


31 posted on 04/29/2014 8:08:33 PM PDT by SunkenCiv (https://secure.freerepublic.com/donate/)
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To: Gamecock; 2A Patriot; 2nd amendment mama; 4everontheRight; 77Jimmy; A Strict Constructionist; ...
South Carolina Ping
Send FReepmail to join or leave this list.

Keep up with what our Congresscritters (House and Senate) are doing. Sign up for the free MegaVote email service here.

32 posted on 04/29/2014 8:23:16 PM PDT by upchuck (Support ABLE, the Anybody But Lindsey Effort. Yes, we are the ABLE!!)
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To: Gamecock

This is amazing news and just brightened my spirits beyond belief.

My mom died of a Glioblastoma multiforme 36 years ago. That they could even diagnos it at they time (those new fangled CT scans) was an amazing plus at the time (the used to “find” brain tumors via xray or post mortum). It was a death sentence...she lived 6 mos and one day (we swear the extra day was her way of flipping off the surgeon who kept casually proclaiming “she won’t last 6 months.) I had found my mom on the kitchen floor (I was in HS). She had had a grand mal seizure.

At the time (again long ago) it was explained to our family they glios grow slowly and once so much of healthy tissue is displaced the “symptoms” start to appear. Amazing to learn that research has brought then to curing happily one patient and I pray ALL others who have this horror.

Thanks for the posting!


33 posted on 04/29/2014 8:33:50 PM PDT by PennsylvaniaMom ( Just because you are paranoid, it doesn't mean they aren't out to get you...)
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To: PennsylvaniaMom

It’s not often I can brighten one’s day. Glad I did so for you!


34 posted on 04/30/2014 5:29:11 AM PDT by Gamecock (The covenant is a stunning blend of law and love. (TK))
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To: Gamecock

This makes sense because polio is very oriented to attacking the CNS. The real trick is how they modified it to only attack the cancerous tissue.


35 posted on 04/30/2014 7:48:51 AM PDT by yefragetuwrabrumuy (WoT News: Rantburg.com)
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To: DannyTN
Who wakes up in the morning and thinks, “You know, if I modify that polio virus, I bet I can get it to kill cancer cells!!!”

Future Nobel Prize winners who don't believe in "The Science is Settled"

36 posted on 04/30/2014 8:17:06 AM PDT by Timocrat (Ingnorantia non excusat)
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To: DannyTN
Who wakes up in the morning and thinks, “You know, if I modify that polio virus, I bet I can get it to kill cancer cells!!!”

Actually, those of us who have advanced degrees in subjects like molecular biology, microbiology, etc., have thoughts like that all the time.

;)

37 posted on 04/30/2014 4:53:26 PM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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To: Gamecock

Interesting stuff.

I will have to see if this has been published yet in the medical literature, so I can see the exact details of what was done.


38 posted on 05/01/2014 3:32:05 AM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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