Replies

I guess this is as good as time as any to start the new thread.

I got excluded from entering the Infusion Center with my wife. Well, not just me...everyone.

I feel like I dropped her off at a day camp she did not want to attend....

So..lets get on with today's chat.

1 posted on 03/11/2020 8:06:12 AM PDT by Vermont Lt

University of Kentucky, University of Louisville, and Bellarmine University are all moving to online classes, amid Coronavirus concerns...until early April. Just announced here on our local Louisville, Kentucky media.

232 posted on 03/11/2020 11:18:37 AM PDT by MasonGal

242 posted on 03/11/2020 11:24:53 AM PDT by Osage Orange (Whiskey Tango Foxtrot)

Thanks for these CV threads.

A treasure trove of good information.

257 posted on 03/11/2020 11:36:08 AM PDT by Jane Long (Praise God, from whom ALL blessings flow.cuase)

A thread from a man going through this illness.

https://threadreaderapp.com/thread/1237308267552034821.html

269 posted on 03/11/2020 11:47:28 AM PDT by Solson (Trump 2020!)

These threads collect posts faster than the corona virus spreads......

Keeping up is a full time job.

312 posted on 03/11/2020 12:16:14 PM PDT by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith...)

Thanks for the thread....
Has anyone seen recent data on ramp up for N95 respirator production?

379 posted on 03/11/2020 1:16:53 PM PDT by CarolinaReaganFan

Tsa is now allowing masks. They have been ordered, but are on back order.

388 posted on 03/11/2020 1:28:29 PM PDT by HollyB

Came across this thread from 2009 when the Swine Flu epidemic was hitting, over 8000 posts.

http://www.freerepublic.com/focus/f-news/2278371

Frankly before this whole thing started, I had almost completely forgotten about it.

I just hope 10 years from now, I would have completely forgotten about this.

697 posted on 03/11/2020 5:21:27 PM PDT by dfwgator (Endut! Hoch Hech!)

I’ve been to that oncology floor many times v l. It gets better.

711 posted on 03/11/2020 5:28:02 PM PDT by Persevero (I am afraid propriety has been set at naught. - Jane Austen)

Just got this email from the VA:

“By now, you’ve heard about the coronavirus disease, known as COVID-19, that’s causing illness around the world.

Fortunately, VA is ready. We have plans in place to protect everyone who gets care, visits or works at one of our facilities.

For Veterans, families and visitors, that means your VA visit will be different for a while.

Call before visiting

If you’re a Veteran seeking medical care, call before visiting—even if you already have an appointment. Or you can sign in to My HealtheVet and send a secure message. You may be able to get diagnosed and receive care through VA telehealth without having to come in at all.

If you visit a VA health care facility, you will be asked screening questions

If you do visit a VA hospital, clinic, community living center or other health care facility, you’ll be met at the entrance by a staff member. They will greet you and ask you some screening questions. Depending on your answers, a VA health care professional will assist you on the next steps of your visit.

Leave time for screening

If you’re a Veteran coming in for an appointment, plan to leave home earlier than usual to allow time for the screening.

We’re doing all we can to make sure everyone in every VA facility—patients, families, visitors, staff and anyone else—stays as safe as possible during this situation.

For the latest VA updates on coronavirus and common-sense tips on preventing the spread of disease, visit https://www.publichealth.va.gov/n-coronavirus/.

For more information about coronavirus, please visit https://www.cdc.gov/coronavirus/2019-ncov/index.html. “

718 posted on 03/11/2020 5:31:41 PM PDT by Oatka

2/8
http://www.freerepublic.com/focus/f-news/3814871/posts

2/9
http://www.freerepublic.com/focus/f-news/3815061/posts

2/10
http://www.freerepublic.com/focus/f-news/3815321/posts

2/11 - 2/12
http://www.freerepublic.com/focus/f-chat/3815664/posts

2/12 - 2/13
http://www.freerepublic.com/focus/f-news/3815980/posts

2/13 - 2/14
http://www.freerepublic.com/focus/f-news/3816298/posts

2/14 - 2/15
http://www.freerepublic.com/focus/f-chat/3816613/posts

2/15 2/16
http://www.freerepublic.com/focus/f-chat/3816849/posts

corona 2/17-2/18
http://www.freerepublic.com/focus/f-chat/3817272/posts

corona virus weekend threwad 2/22/2020
http://www.freerepublic.com/focus/f-chat/3818597/posts

thread 1
http://www.freerepublic.com/focus/f-chat/3818863/posts

thread 2
http://www.freerepublic.com/focus/f-chat/3819175/posts

Thread 3
http://www.freerepublic.com/focus/chat/3819472/posts

Thread 4
http://www.freerepublic.com/focus/f-chat/3819771/posts

Thread 5 here:
http://www.freerepublic.com/focus/f-chat/3820145/posts

thread 6
http://www.freerepublic.com/focus/f-chat/3820357/posts

thread 7
http://www.freerepublic.com/focus/chat/3820821/posts

thread 8
http://www.freerepublic.com/focus/f-chat/3821104/posts

thread 9
http://www.freerepublic.com/focus/f-chat/3821430/posts

thread 10
http://www.freerepublic.com/focus/chat/3821921/posts

thread 11
http://www.freerepublic.com/focus/chat/3822365/posts

thread 12
http://www.freerepublic.com/focus/f-chat/3822786/posts

thread 13
http://www.freerepublic.com/focus/f-chat/3823193/posts

thread 14
http://www.freerepublic.com/focus/f-chat/3823556/posts

Coronavirus Disease (COVID-19)
https://ourworldindata.org/coronavirus#the-symptoms-of-covid-19

realtime corona virus updates
https://www.globaltimes.cn//content/1177737.shtml

https://bnonews.com/index.php/2020/02/the-latest-coronavirus-cases/

https://kungflu.net/

Corona Virus - COVID-19 / SARS-CoV-2: LIVE stats and graphs
https://covid2019.azurewebsites.net/

https://www.worldometers.info/coronavirus/

Johns Hopkins Corona Virus map
https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

This document shows how COVID-19 attracts to cell receptors of those with more ACE2 receptors
https://jvi.asm.org/content/jvi/early/2020/01/23/JVI.00127-20.full.pdf

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations
https://www.nature.com/articles/s41421-020-0147-1

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
https://link.springer.com/article/10.1007/s00134-020-05985-9

Possibility that HIV virus is in Corona virus, intentional, man made
https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1.full.pdf

Coronavirus far more likely than Sars to bond to human cells due to HIV-like mutation, scientists say
https://www.scmp.com/news/china/society/article/3052495/coronavirus-far-more-likely-sars-bond-human-cells-scientists-say

“All the crematoriums of Hubei are backed up & cannot take bodies.”
https://threadreaderapp.com/thread/1228451610868830209.html

China Coronavirus: Tough Realities & Possibility of Global Pandemic—Epidemic Reporter Laurie Garrett
https://youtu.be/Jcthdee6CXs

https://jrnyquist.blog/2020/01/30/general-chis-nasty-wuhan-soup-a-recipe-for-biowar/
General Chi’s Nasty Wuhan Soup: A Recipe for BioWar

Chinese general’s speech on the need for land to expand greater china and to do it they must kill Americans and Canadians
https://chinawatchcanada.blogspot.com/2014/03/the-vice-chairman-of-chinas-military.html

China has posited that the high rate of mortality in Wuhan was prior exposure to SARS. I’m not sure if Italy was involved with the SARS, but they’re a good test of that Chinese claim.
https://www.sciencedirect.com/science/article/pii/S1286457920300344?via%3Dihub

Corona Virus has many mutations and subtypes
https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwaa036/5775463

Researchers in China have found that two different types of the new coronavirus could be causing infections worldwide.
https://www.cnbc.com/2020/03/04/coronavirus-chinese-scientists-identify-two-types-covid-19.html

US hospitals are preparing for 96 MILLION coronavirus infections and nearly HALF A MILLION deaths, leaked documents reveal
https://www.dailymail.co.uk/news/article-8085175/US-hospitals-prepare-96-MILLION-coronavirus-cases-HALF-MILLION-deaths-leaked-papers-show.html

California man had coronavirus before he boarded Grand Princess, cruise ship official says
https://www.latimes.com/california/story/2020-03-07/spread-of-coronavirus-on-grand-princess-ship-raises-public-health-alarms

Coronavirus: Northern Italy to ‘quarantine 16 million people’
https://www.bbc.com/news/world-middle-east-51787238

something big missing in the conversation re: how fast we could potentially develop and deploy a vaccine at large scale.
https://threadreaderapp.com/thread/1236744502317961216.html

coronavirus causes permanent lung damage
https://www.bing.com/search?q=coronavirus+causes+permanent+lung+damage&form=APMCS1&PC=APMC

Genomic epidemiology of novel coronavirus (hCoV-19)
https://nextstrain.org/ncov

Earlier today I published a story showing that Iran’s #COVID19 numbers—already frighteningly high—are possibly hundreds of times (!) higher than officially acknowledged. Here I’ll run through my methods for arriving at this figure:
https://threadreaderapp.com/thread/1237067952018653185.html

779 posted on 03/11/2020 6:17:13 PM PDT by RaceBannon (Rom 5:8 But God commendeth his love toward us, in that, while we were yet sinners, Christ died for)

The shopping reports will be interesting tomorrow, and a few floating around tonight.

910 posted on 03/11/2020 7:57:53 PM PDT by Will88 (The only people opposing voter ID are those benefiting from voter fraud.)

To: Vermont Lt; BobL; Kartographer; JRandomFreeper; Tilted Irish Kilt; Jane Long; LilFarmer; ...

923 posted on 03/11/2020 8:09:42 PM PDT by Tolerance Sucks Rocks (Show me the people who own the land, the guns and the money, and I'll show you the people in charge.)

To: Vermont Lt; All

Aerosol transmission about to be officially acknowledged.

http://freerepublic.com/focus/f-news/3823782/posts

Time to strap in.

1,005 posted on 03/11/2020 9:11:03 PM PDT by Mariner (War Criminal #18)

a note from the Philippines.

President Duterte is being tested, and the Senate is closed. Several cases in a Manila suburb (Marikina). Schools in Manila are closed for now.
The big Agricultural trade fair has been postponed (we sell organic rice and were supposed to set up a kiosk and now we will stay home).

Our area in the provinces is still okay, but since many folks have relatives working in Manila and coming home on weekends, it’s just a matter of time.

1,054 posted on 03/11/2020 11:51:11 PM PDT by LadyDoc (liberals only love politically correct poor people)

I think I had COVID-19 back in November. Does that matter for anything?

1,097 posted on 03/12/2020 4:18:53 AM PDT by Musket (It's very simple:<i>your quoted text pasted here</i><p> produces Quoted Italic with paragraph break)

So the US has 38 deaths now?

https://www.worldometers.info/coronavirus/

1,112 posted on 03/12/2020 5:37:25 AM PDT by HollyB

“Time to stay calm and continue on....”

This morning we were driving home from our tax guy’s place through a pretty desolate area. Then we saw a home-made sign stuck in a field, about 5’ x 5’, that said:

IT WILL
BE OK

Odd.

1,162 posted on 03/12/2020 7:27:28 AM PDT by MayflowerMadam ("Worry does not empty tomorrow of its sorrow; it empties today of its strength" - Corrie ten Boom)

1,208 posted on 03/12/2020 8:39:48 AM PDT by RightGeek (FUBO and the donkey you rode in on)

treatment article - a bit old but highly relevant and not widely circulated: http://www.natap.org/2020/newsUpdates/020620_03.htm Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Dear Editor, In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27, 2020, the Chinese authorities reported 2835 confirmed cases in mainland China, including 81 deaths. Additionally, 19 confirmed cases were identified in Hong Kong, Macao and Taiwan, and 39 imported cases were identified in Thailand, Japan, South Korea, United States, Vietnam, Singapore, Nepal, France, Australia and Canada. The pathogen was soon identified as a novel coronavirus (2019-nCoV), which is closely related to sever acute respiratory syndrome CoV (SARS-CoV).2 Currently, there is no specific treatment against the new virus. Therefore, identifying effective antiviral agents to combat the disease is urgently needed. An efficient approach to drug discovery is to test whether the existing antiviral drugs are effective in treating related viral infections. The 2019-nCoV belongs to Betacoronavirus which also contains SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV). Several drugs, such as ribavirin, interferon, lopinavir-ritonavir, corticosteroids, have been used in patients with SARS or MERS, although the efficacy of some drugs remains controversial.3 In this study, we evaluated the antiviral efficiency of five FAD-approved drugs including ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine and two well-known broad-spectrum antiviral drugs remdesivir (GS-5734) and favipiravir (T-705) against a clinical isolate of 2019-nCoV in vitro. Standard assays were carried out to measure the effects of these compounds on the cytotoxicity, virus yield and infection rates of 2019-nCoVs. Firstly, the cytotoxicity of the candidate compounds in Vero E6 cells (ATCC-1586) was determined by the CCK8 assay. Then, Vero E6 cells were infected with nCoV-2019BetaCoV/Wuhan/WIV04/20192 at a multiplicity of infection (MOI) of 0.05 in the presence of varying concentrations of the test drugs. DMSO was used in the controls. Efficacies were evaluated by quantification of viral copy numbers in the cell supernatant via quantitative real-time RT-PCR (qRT-PCR) and confirmed with visualization of virus nucleoprotein (NP) expression through immunofluorescence microscopy at 48 h post infection (p.i.) (cytopathic effect was not obvious at this time point of infection). Among the seven tested drugs, high concentrations of three nucleoside analogs including ribavirin (half-maximal effective concentration (EC50) = 109.50 μM, half-cytotoxic concentration (CC50) > 400 μM, selectivity index (SI) > 3.65), penciclovir (EC50 = 95.96 μM, CC50 > 400 μM, SI > 4.17) and favipiravir (EC50 = 61.88 μM, CC50 > 400 μM, SI > 6.46) were required to reduce the viral infection (Fig. 1a and Supplementary information, Fig. S1). However, favipiravir has been shown to be 100% effective in protecting mice against Ebola virus challenge, although its EC50 value in Vero E6 cells was as high as 67 μM,4 suggesting further in vivo studies are recommended to evaluate this antiviral nucleoside. Nafamostat, a potent inhibitor of MERS-CoV, which prevents membrane fusion, was inhibitive against the 2019-nCoV infection (EC50 = 22.50 μM, CC50 > 100 μM, SI > 4.44). Nitazoxanide, a commercial antiprotozoal agent with an antiviral potential against a broad range of viruses including human and animal coronaviruses, inhibited the 2019-nCoV at a low-micromolar concentration (EC50 = 2.12 μM; CC50 > 35.53 μM; SI > 16.76). Further in vivo evaluation of this drug against 2019-nCoV infection is recommended. Notably, two compounds remdesivir (EC50 = 0.77 μM; CC50 > 100 μM; SI > 129.87) and chloroquine (EC50 = 1.13 μM; CC50 > 100 μM, SI > 88.50) potently blocked virus infection at low-micromolar concentration and showed high SI (Fig. 1a, b). Remdesivir has been recently recognized as a promising antiviral drug against a wide array of RNA viruses (including SARS/MERS-CoV5) infection in cultured cells, mice and nonhuman primate (NHP) models. It is currently under clinical development for the treatment of Ebola virus infection.6 Remdesivir is an adenosine analogue, which incorporates into nascent viral RNA chains and results in pre-mature termination.7 Our time-of-addition assay showed remdesivir functioned at a stage post virus entry (Fig. 1c, d), which is in agreement with its putative anti-viral mechanism as a nucleotide analogue. Warren et al. showed that in NHP model, intravenous administration of 10 mg/kg dose of remdesivir resulted in concomitant persistent levels of its active form in the blood (10 μM) and conferred 100% protection against Ebola virus infection.7 Our data showed that EC90 value of remdesivir against 2019-nCoV in Vero E6 cells was 1.76 μM, suggesting its working concentration is likely to be achieved in NHP. Our preliminary data (Supplementary information, Fig. S2) showed that remdesivir also inhibited virus infection efficiently in a human cell line (human liver cancer Huh-7 cells), which is sensitive to 2019-nCoV.2 Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d). Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration. The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90 μM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500 mg administration.11 Chloroquine is a cheap and a safe drug that has been used for more than 70 years and, therefore, it is potentially clinically applicable against the 2019-nCoV. Our findings reveal that remdesivir and chloroquine are highly effective in the control of 2019-nCoV infection in vitro. Since these compounds have been used in human patients with a safety track record and shown to be effective against various ailments, we suggest that they should be assessed in human patients suffering from the novel coronavirus disease.

1,219 posted on 03/12/2020 8:53:32 AM PDT by Triple (Socialism denies people the right to the fruits of their labor, and is as abhorrent as slavery)

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