Posted on 09/21/2022 3:20:34 PM PDT by ConservativeMind
Obesity is a known risk factor for at least 13 types of cancer. Dr. Elda Grabocka found that stress granules are much more abundant in obesity-related pancreatic cancer compared to non-obese patients, and importantly, blocking their formation stopped cancer growth in animals.
"Stress granule research is exploding right now, but there's still a lot we don't know regarding what they're made of and how they work," says Dr. Grabocka. "This work is the first to show that an overload of stress granules enables the tumor-growth in the pancreas. Our experiments in mice also showed a complete reversal of cancer growth in the lab."
Stress granules are an unusual sort of cellular compartment. The cell generates these non-membraned organelles in response to stress, and to protect the cell from stress-induced self-destruction. Many cancers produce much higher levels of stress granules than normal cells, to help protect the cancer cells.
Dr. Grabocka's team created a mouse model of cancer that blocked the formation of stress granules in pancreatic cancer in mice, they saw a 50% reduction in pancreatic cancer growth in mice. "This suggested to us that the cancers in obese mice might be dependent on stress-granules for their growth. When we take away the thing a cancer depends on to live, we kill the cancer."
And the most striking difference was their overall survival. Normally in these models of pancreatic cancer, mice die very quickly, within 50-60 days. In obese mice whose tumor stress granules were blocked, 40% were cancer free after 300 days, with no sign of the cancer anywhere in the animals' bodies. "This magnitude of response is extraordinarily rare," says Dr. Grabocka.
These experiments showed that stress granules weren't just present in cancer cells, they were actually driving the growth of cancer at the very start.
(Excerpt) Read more at medicalxpress.com ...
Also, eliminating obesity early stops this segment of cancers from getting started, of which obesity appears to be responsible for at least 33% of pancreatic cancers.
Never heard of stress granules. What causes them and how to get rid of them?
no more stress granules sprinkled on my Cheerios anymore for me ...
When my wife was being treated for pancreatic cancer one of the things I read was to care careful about making leaps from mice to people. Any researcher worth their salt should be able to cure cancer in a mouse. During it in humans is a whole different ball of cancer.
Ways to reduce
Targeting stress granules: A novel therapeutic strategy for human diseases
How to Keep Stress Granules from Wreaking Havoc On Your Body
Thanks will check this out later later.
Utter BS.
So-called ‘stress granules’ are a biochemical response to inflammation & moderate the immune system.
You’re focusing on the wrong target.
If the biochemical topic - ribonucleoproteins, but one of many proteinaceous membrane-less organelles - has any relation to cancer whatsoever, my bet is that ‘SG’ will someday play a role in cancer treatment.
That stated, it IS possible that an imbalanced system may produce too much ‘SG’ and thus inhibit the immune system response, thereby leading to ‘cancer’...
...but I also bet that absolutely nothing will be done about it in our lifetimes:
There’s more money in what is currently (and laughably) referenced as ‘cancer treatment’.
The research behind ‘SG’ is appalling, and it hearkens to research which delivered us one of the greatest medical hoaxes of the 20th century: The ‘lipid hypothesis’.
The bottom line is that ‘SG’ is rooted in micro RNA biochemical processes and if anyone here believes this research which professes “there’s still a lot we don’t know regarding what they’re made of and how they work” will do anything but increase hypochondria, I have a fountain in a cave in my backyard which professes to do much more. /a
I got to thinking about Lecithin and it's role as an emulsifier. Went looking for information on whether Lecithin would reduce stress granules.
I didn't find that, but Lecithin does reduce stress.
"The results of the study showed that the 400 mg doses of soy lecithin complex was significantly able to reduce the stress response of the subjects as measured by falling levels of adrenocorticotropic hormone (ACTH) and cortisol. However the changes were not seen at higher doses of the supplement.
You’re overcomplicating it.
When it comes to stress (if that’s a concern), don’t underestimate the benefits of Oxytocin.
No chemical ingestion required.
Well I'm sure that works for Laz, but my oxytocin hasn't been boosted in a while. A long while.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.