New study shows repeated stress accelerates aging of the eye (Higher eye pressure in the young better than in the old)

Medical Xpress / University of California, Irvine / Aging Cell ^ | Nov. 21, 2022 | Qianlan Xu et al

[ConservativeMind]

New research suggests aging is an important component of retinal ganglion cell death in glaucoma, and that novel pathways can be targeted when designing new treatments for glaucoma patients.

Dorota Skowronska‐Krawczyk, Ph.D. describes the transcriptional and epigenetic changes happening in aging retina.

The team shows how stress, such as intraocular pressure (IOP) elevation in the eye, causes retinal tissue to undergo epigenetic and transcriptional changes similar to natural aging. And, how in young retinal tissue, repetitive stress induces features of accelerated aging including the accelerated epigenetic age.

"Our work emphasizes the importance of early diagnosis and prevention as well as age-specific management of age-related diseases, including glaucoma," said Skowronska-Krawczyk. "The epigenetic changes we observed suggest that changes on the chromatin level are acquired in an accumulative way, following several instances of stress. This provides us with a window of opportunity for the prevention of vision loss, if and when the disease is recognized early."

In humans, IOP has a circadian rhythm. In healthy individuals, it oscillates typically in the 12-21 mmHg range and tends to be highest in approximately two thirds of individuals during the nocturnal period. Due to IOP fluctuations, a single IOP measurement is often insufficient to characterize the real pathology and risk of disease progression in glaucoma patients.

Long-term IOP fluctuation has been reported to be a strong predictor for glaucoma progression. This new study suggests that the cumulative impact of the fluctuations of IOP is directly responsible for the aging of the tissue.

"Our work shows that even moderate hydrostatic IOP elevation results in retinal ganglion cell loss and corresponding visual defects when performed on aged animals," said Skowronska-Krawczyk.

[ConservativeMind]

Somewhat higher eye pressures cause problems for older people, so please get your pressure checked and lowered, possibly with drugs or supplements, as you age.

[ConservativeMind]

Oral Omega-3 Supplementation Lowers Intraocular Pressure in Normotensive Adults

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931260/

Mirtogenol potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects (French maritime pine bark combined with bilberry)

https://pubmed.ncbi.nlm.nih.gov/20505841/

There are a few other supplements that could be helpful, but reducing blood pressure might help, too.

[ConservativeMind]

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[Angelino97]

What do people think of N-Acetyl Carnosine eyedrops?

[sauropod]

bkmk

[bunkerhill7]

I eat stress for breakfast.

[entropy12]

Exercising every other day in gym, I have zero health problems at age 82. Perfect eye retina and pressure.

[moovova]

This girl's in trouble...