Novel senomorphic agent of natural origin found to target aging (Rutin can greatly help chemo)

Medical Xpress / Chinese Academy of Sciences / Aging Cell ^ | July 31, 2023 | Chen Na / Hanxin Liu et al

[ConservativeMind]

Since the discovery of hallmark features of senescence such as cell cycle arrest, apoptosis resistance and development of a senescence-associated secretory phenotype (SASP), efforts in understanding how senescent cells drive aging have grown exponentially.

Targeting senescent cells with senolytics or senomorphics hold the potential to mitigate the vast majority of age-related disorders.

However, the major challenge in developing novel senotherapies is the paucity of antiaging agents that have decent safety profiles.

Prof. Sun Yu recently performed large scale screening of a natural medicinal agent library for senotherapeutic candidates and validated several agents, which showed their excellent potential to serve as senomorphics.

Rutin, a small molecule phytochemical component enriched in an array of plants, exhibited an outstanding capacity in targeting senescent cells by reducing the expression of a full spectrum SASP.

In-depth investigation revealed that Rutin mainly curtails the acute stress-associated phenotype (ASAP).

Such a mechanism allows Rutin to effectively control the impact of senescent cells in generating a highly pro-inflammatory extracellular microenvironment.

Preclinical data of Sun's lab suggested that Rutin has an excellent efficacy in promoting chemotherapeutic outcomes, such as in the case of mitoxantrone treatment. Although cancer cells also become senescent in response to various chemotherapeutic regimens, they cannot repopulate and expand continuously within tumor foci during and/or after anticancer regimens. However, stromal cell subpopulations tend to become senescent in response to anticancer treatments, and confer surviving cancer cells with remarkable resistance to anticancer drugs.

For this reason, senolytics and/or senomorphics are increasingly proposed as adjuvant treatments to deplete senescent cells in vivo. As effective SASP inhibitors, senomorphic agents such as Rutin can be used as ideal alternatives to senolytics, as they preserve the less SASP-dependent pro-immunogenic capacity of senescent cells, particularly tumor immunosurveillance in the context of cancer cell survival.

[ConservativeMind]

Rutin is a common supplement and is naturally available in many foods, including capers, apples, green rooibos, buckwheat, and citrus fruits.

[ConservativeMind]

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[sauropod]

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[Pete from Shawnee Mission]

Thanks! No Chemo here, but Capers in my Bruscetta it is!

[NetAddicted]

Read later.

[Tilted Irish Kilt]

Sources of “Rutin” :

”Rutin is the glycoside combining the flavonol quercetin and the disaccharide rutinose.
It is a flavonoid glycoside found in a wide variety of plants, including citrus.”

https://en.wikipedia.org/wiki/Rutin

[Tunehead54]

I don’t know how this helps but I make a mean omelet with capers, good Brie, avocado and bacon. Usually with two halves of English Muffins.

What are my chances? ;-)