Posted on 11/27/2004 12:56:17 PM PST by neverdem
Condoleezza Rice, the national security adviser, shares at least one thing with millions of other American women: she had fibroids, benign tumors in the uterus that required treatment.
Ms. Rice, the nominee for secretary of state, entered the hospital for an overnight stay last week to undergo a procedure - uterine artery embolization - that is rapidly becoming an alternative to major surgery for troublesome fibroids.
For most women, fibroids, consisting of muscle and fibrous tissue, are no bother. But for millions of others, fibroids can be so large (in some cases, the size of a melon) or so numerous that they cause discomfort, severe bleeding, anemia, urinary frequency and other symptoms.
What causes fibroids is unknown, although estrogen is known to promote their growth. More than one woman in five age 40 and older has the tumors, with higher rates among black women.
For decades, major surgery - a hysterectomy to remove the uterus or a myomectomy to remove selected fibroids while leaving the uterus in place - was the main therapy for women whose symptoms were not controlled by oral contraceptives or other hormonal therapies. About 30 percent of the 600,000 hysterectomies performed in the United States each year are for fibroids.
With the introduction of technologies like ultrasound, C.T. scans, magnetic resonance imaging and new drugs, however, doctors have in recent years developed a number of alternative therapies.
This year in the United States, about 13,000 women are expected, like Ms. Rice, to choose the embolization technique, which is less invasive than surgery. French doctors first reported the embolization procedure in 1995. Since then, the number of the procedures has grown, in part because of direct-to-consumer advertising by interventional radiologists, who perform them.
Embolization involves injecting pellets the size of grains of sand, made from plastic or gels, into uterine arteries to stop blood flow and shrink the tumors by starvation. The procedure is so named because the pellets are emboli, objects that lodge and stop blood flow. M.R.I. scans are often used to screen out fibroid patients who are not candidates for the embolization procedure.
In performing the procedure, interventional radiologists insert a thin tube into an artery in the groin and thread it up to the main uterine artery in the pelvis. A dye is injected that outlines the smaller arterial branches on an X-ray, producing a map that guides injection of pellets through the tube into the arteries that nourish the fibroids.
"Of the patients we see, at least a third have fibroids the size of an orange or larger," and the size does not influence the outcome of the procedure, said Dr. John H. Rundback, an interventional radiologist at Columbia University.
The procedure, which may be painful, usually lasts 60 to 90 minutes. Most patients also experience intense pain for several hours afterward and stay overnight in the hospital. For some patients, the pain persists for several days, or even two weeks. Surgery for fibroids requires a longer hospital stay.
Additional complications from the embolization procedure can include abscesses and other infections; heavy uterine bleeding; early menopause from the pellets damaging the ovaries; or destruction of the uterus, requiring emergency surgery.
Although the procedure is safe, "there are still significant uncertainties about the procedure, especially in terms of future fertility and long-term outcomes," said Dr. Evan R. Myers, chief of the division of clinical and epidemiologic research in Duke University's department of obstetrics and gynecology.
Judging the safety and effectiveness of embolization compared with to other therapies is hard because randomized controlled studies are lacking and because earlier studies did not report how different symptoms responded to different treatments, Dr. Myers said.
"It is amazing that for a condition as common as fibroids, that has such significant impact on reproductive-age women, there is not a lot of high-quality scientific evidence for many of the things that are done for fibroids," Dr. Myers said.
"There still is no gold standard randomized trial comparing embolization to the other interventions," he added. This is largely because patients and physicians have such strong preferences for one method or another that it is hard to recruit enough patients for clinical trials comparing the embolization procedure to hysterectomy, myomectomy, hormonal and other therapies.
Dr. Myers directs a registry that the Society of Interventional Radiology has created to monitor the outcome of 3,000 women who have undergone the embolization procedure. He said that the effectiveness and complication rates for embolization seem comparable to surgery. But there is insufficient information to draw conclusions about the procedure's safety for women who desire to become pregnant, according to Dr. Myers, the interventional society and the American College of Obstetricians and Gynecologists.
In very rare cases - less than 1 percent - fibroids are cancerous. The cancers usually develop among postmenopausal women and the embolization procedure is not recommended for that group. Biopsies are not routinely performed on fibroid patients before embolization, and even if they were done, biopsies would not be able to detect cancerous fibroids deep in the uterine muscle. So statistically, as more women undergo embolization procedures, the cancers are unlikely to be detected in the very few patients who have them.
"That small risk has to go into the counseling before the embolization procedure," said Dr. Howard T. Sharp, chief of the general division of obstetrics and gynecology at the University of Utah.
Dr. Sharp said he believed that there were probably more cases of cancer than the single report in the medical literature, because doctors often "don't report the bad outcomes."
While some researchers are trying to study the embolization procedure further, others, like Dr. Elizabeth Stewart of the Brigham and Women's Hospital in Boston, are testing another fibroid treatment, the ExAblate 2000 System, that won approval from the Food and Drug Administration last month.
The system, made by InSightec Ltd. of Israel, uses ultrasound to destroy the fibroids with heat and M.R.I. to map the uterine anatomy and monitor the degree of fibroid destruction from a repeated application of multiple ultrasound waves on the tumor. The device centers the ultrasound waves similarly to the way a magnifying glass focuses light.
The patient remains in an M.R.I. machine for about three hours and then can go home. Initial studies found that serious side effects occurred in 2 percent of cases, compared with 13 percent among women who underwent a hysterectomy, Dr. Stewart said. Additional studies are being conducted at a small number of hospitals. The procedure is intended for women who have completed childbearing or who do not intend to become pregnant.
This article is a sight for sore eyes. My mother had terrible fibroids and had a hysterectomy by the time she was 23. I have fibroids that cause me great pain, to the point where I can't sit down for long. I've been looking into options for a while but I could never figure out what was best, and I want the hysterectomy to be a last resort, just in case I want children someday.
But it has been hard to find information that made sense. Thanks for this article.
Unless there's a fistula - an abnormal connection between arteries and veins - they should clog up the near end of the capillaries and arterioles. The blood starts from the heart to aorta with branches breaking off to form arteries serving organs, muscles, etc. to arterioles(little arteries) to capillaries where the blood goes through as cells in single file in the tissue it serves. The various blood cells types are suspended in plasma. Think of the root system and branches in a plant.
The blood goes back from the capillaries which join back to form venules(little veins) which join to form veins and then finally form both the inferior and superior vena cava which deliver the blood back to your heart's right atrium from below and above, respectively.
Look for a very experiened doctor who deals only with woman gyno surgeries and especially problems as well as fertilty issues. They can see where the fibroids are with the ultra sounds - Good Luck!
I had very big fibroids removed - - now I have them back. THis is definitely annoying the heck out of me and I find that I do not want to really face this again!
It helps to stay off of sugar and caffine. Those things love sugar and caffine!
"Fibroids" 'The complete guide to taking care of you physical, emotional, and sexual well-being'
by: Johanna Skilling
have this book recommended by my chiropractor/keniesologist (sp?) -have not read it yet.
My wife had many problems with fibroids, cysts, and bleeding, and recently had a hysterectomy. Life has been great since! I know hysterectomies get a bad rap, but if a woman has already had children, it is the way to go.
Dang. Going up the femoral artery. That's gotta hurt!
Mrs. VS is totally correct. The patient could bleed to death.
Fibroids: The Complete Guide to Taking Charge of Your Physical, Emotional, and Sexual Well-Being. Johanna Skilling, Eileen Hoffman. Marlowe & Company; 1st edition (January 15, 2000); ISBN: 1569246203.
Review by Amazon.com, Joan Price - Author Johanna Skilling sees fibroids as "an interruption" of your uterus, blood flow, physical well-being, and lifestyle, as well as a disruption of your self-image and self-esteem, which may leave you feeling shamed, damaged, and helpless. Skilling is not a doctor; she is a woman with fibroids. When she was diagnosed, she read everything she could find, interviewed medical experts, and compiled stories from other women. She presents information about conventional medical treatments, alternative therapies, and diet, along with tips, anecdotes, and humor (for example, the "top 10 things you resemble while taking an MRI" includes "one of those pretzels with cheese filling" and "a lime wedge in the neck of a beer bottle"). Skilling's aim in writing this book is to provide both a source of information about fibroids and a "support group in a book" for women with fibroids to find comfort and sharing. She succeeds.
My mom just had surgery to remove a fibroid the size of a melon. It was causing her more and more pain + bleeding along with anemia. They gave her a hysterectomy as well. She says she looks like she lost 10 pounds.
I was plagued by fibroids in my 30s, with excessive bleeding and clots, and I took Vitex, which worked for me to make them disappear. Vitex will even out any female hormone imbalance. Health food store hasit in pills or liquid tincture.
Not so. For example, hysterectomy is, I believe, the only treatment for a patient presenting with life-threatening hemorrhaging caused by benign fibroids.
I'm with mewzilla.
Intentional introduction of emboli (especially in the form of probably non-resorbable plastic pellets) into the circulatory system, which is, by definition, continuous, does not seem to me to be the smartest strategy.
This treatment modality assumes the absence of fistulae (as you point out) as well as the existence of theoretically predicted relative size of ductwork vs. pellets and aggregated pellets.
Leave it to the French to push this thing.
Read "No More Hysterectomies" by Dr. Vicki Hufnagel. This is a quote from her. She has saved hundreds of women from hysterectomies and women have gone on to have children after other doctors wanted to give them a hysterectomy.
She is 50 years ahead of her time and has innovative ways of helping women with fibroids, etc. I have spoken with dozens of her patients and they all agree.
Read "No More Hysterectomies" by Vicki Hufnagel. Search, search, search on the internet for all you can find on this. You should never need a hysterectomy for fibroids at your young age. But, you will need the surgery that Dr. Hufnagel performs. She has saved many women from hysterectomies. There are a few other doctors out there who are experts at removing fibroids without resorting to a hysterectomy....but just a few. You have to search and do your homework. Good luck.
Seems like the cure is worse than the problem, doesn't it?!
Vitex...do you know what is in that?
Vitex? I not heard of 'vitex' - is it a herbal remedy?
I am taking chaste berries - I read about this as a help - but of course any 'natural' remedy really takes alot of time and consistancy and probably a variety of supplements working together.
I am going right now to check my Nutritional Healing book by the Balch couple - MDs
I suspect if you followed Dr.Hufnagel around for a week or two and watched the surgical schedule you will find she does hysterectomies. You never say never in terms of prohibiting a proceedure. You will find a need to do it for certain surgical indications. I would agree that the current day indications have substantially shrunk from what it was 25 years ago.
I believe Vitex and Chasteberries are one and the same.
It has been a while, but I believe Vitex is the Latin name for Chasteberries.
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