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"Rimonabant blocks a protein in brain cells that allows cannabis, the active ingredient in marijuana, to work. It also blocks the body's own versions of cannabis, the so-called endocannabinoids. Marijuana is supposed to increase appetite. So a drug that blocks cannabis, it seems logical, should suppress the appetite.

"Obese people have more receptors for endocannabinoids than thin people, said Dr. F. Xavier Pi-Sunyer, a professor of medicine at Columbia University and the principal investigator of a large rimonabant study in the United States and Canada. The drug does not completely block these receptors, Dr. Pi-Sunyer said.

"The idea of blocking these receptors worked in animals.

"For example, mice that were genetically engineered so they could not respond to endocannabinoids ate less and were thinner than normal. And when scientists at Sanofi-Aventis gave rimonabant to obese mice, the animals ate much less, lost 20 percent of their body weight, and had lower levels of blood glucose and lipids, risk factors for diabetes and heart disease.

"Rimonabant, said Dr. Jeffrey Friedman, an obesity researcher at Rockefeller University, "is the first in what I think will be a wave of rational therapies" that attack what has recently been learned about how eating is controlled. But with rimonabant, he said, "the issue is, what's the safety and efficacy?"

"The company says it has enrolled more than 13,000 subjects in clinical trials asking if the drug helps with

1 posted on 12/05/2004 4:31:22 AM PST by shrinkermd
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To: shrinkermd

Sanofi-Aventis.....hhhmmmm, chart looks pretty good.....note to self - call broker......


2 posted on 12/05/2004 4:34:53 AM PST by anniegetyourgun (All taglines should be knee-length.)
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To: shrinkermd

bttt


4 posted on 12/05/2004 4:37:05 AM PST by Guenevere
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To: shrinkermd
It will make a person uninterested in fattening foods, they have heard from news reports and word of mouth. Weight will just melt away, and fat accumulating around the waist and abdomen will be the first to go. And by the way, those who take it will end up with higher levels of H.D.L., the good cholesterol. If they smoke, they will find it easier to quit. If they are heavy drinkers, they will no longer crave alcohol.

Cool.

But I quit alcohol (I no longer will even take a single beer or a single glass of wine) by being part of a 12 step program, and I lost 60 lbs by walking a lot and eating small meals.

But still, a shortcut might be nice for some. And there's that additional 40 lbs I want to lose... :o)

7 posted on 12/05/2004 4:44:59 AM PST by Lazamataz ("Stay well - Stay safe - Stay armed - Yorktown" -- harpseal)
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To: shrinkermd
I nominate Michael Moore as a test pig!
 

8 posted on 12/05/2004 4:47:54 AM PST by Rain-maker
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To: shrinkermd

Too good to be true?

Read: if something works this well, there just has to be some downside ;D


10 posted on 12/05/2004 4:54:36 AM PST by ECM
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To: shrinkermd
Sanofi-Aventis
174, avenue de France
Paris,  75013
Web Site: http://www.sanofi-synthelabo.com/
 
Chart
 
http://finance.yahoo.com/q/mb?s=SNY
 

Obesity drug offers bit of hope, bundle of hype
Kansas City Star (subscription), MO -
4 hours ago

By GINA KOLATA. To people who have struggled for a lifetime to lose weight, the new drug called rimonabant sounds like a dream come true. ...
Myths grow around drug for dieters
San Jose Mercury News (subscription), CA - 1 hour ago
By Gina Kolata. To people who have struggled for a lifetime to lose weight, the new drug called rimonabant sounds like a dream come true. ...
Anti-obesity medicine stirs up whirlwind of hopes
Arizona Republic, AZ - 6 hours ago
To people who have struggled for a lifetime to lose weight, the new drug called rimonabant sounds like a dream come true. It will ...
Weight-loss drug's hype may be myth
Contra Costa Times (subscription), CA - 1 hour ago
By Gina Kolata. • It will melt away fat, with weight around the waist and abdomen the first to go. • It will increase levels of HDL, the good cholesterol. ...

13 posted on 12/05/2004 5:00:44 AM PST by Rain-maker
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To: shrinkermd

Sounds like a miracle drug

You sure this isn't a fake story


24 posted on 12/05/2004 5:48:30 AM PST by uncbob
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To: shrinkermd

This is too terrible to think about. Can't get high and can't eat Oreo's?


26 posted on 12/05/2004 6:15:48 AM PST by RtWngr (Being tolerant of the intolerant is pretty stupid actually.)
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To: shrinkermd

I feel terrible seeing the new Carl's Jr. commercial of a Caddilac crashing into a deli. I must have a supersized new Pastrami Burger before I diet! :)


29 posted on 12/05/2004 6:23:00 AM PST by goldstategop (In Memory Of A Dearly Beloved Friend Who Lives On In My Heart Forever)
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To: vharlow

ping


32 posted on 12/05/2004 6:30:07 AM PST by lepayne
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To: shrinkermd

How about diet and exercize instead of sloth and gluttony.

How complicated is that?


48 posted on 12/05/2004 12:19:38 PM PST by broadsword (When Islam creeps into a human society, oppression, misogyny and terror come hard on its heels.)
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To: shrinkermd

bump


57 posted on 12/05/2004 1:30:44 PM PST by Centurion2000 (Truth, Justice and the Texan Way)
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To: shrinkermd
But what are the side effects?

Does it make your arms and legs fall off, cause you to sprout a 3rd eye on your buttocks, and grow long toenails?

61 posted on 12/05/2004 2:21:55 PM PST by Old Phone Man
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