as of 3 hours ago, I quit taking 375 mg naproxen twice daily after nearly 2 years of it. No need for me to discuss it with anyone.
Also, the reason I was switched to it from Motrin is that motrin-Advil-ibuprofen crowds the cox-2 receptor on platelets, preventing the anti-platelet benefit of aspirin. (Feb 03 NEJM, if memory serves)
Soooo....what ARE you taking now? Anything? I'm in PAIN!!! And, at the end of the 48 hours since my last Naproxen.....it's gonna be a REALLY BAD night if I don't take something.
Discovery of Unexpected Ibuprofen-Aspirin Interaction will Force a Change in Ibuprofen Prescribing
New England Journal of Medicine
A new study published in the December 20, 2001 issue of the New England Journal of Medicine has found that ibuprofen blocks the heart-protecting effects of aspirin.
The study entitled Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin by Francesca Catella-Lawson, M.D and her colleagues concludes: "The concomitant administration of ibuprofen but not rofecoxib, acetaminophen, or diclofenac antagonizes the irreversible platelet inhibition induced by aspirin. Treatment with ibuprofen in patients with increased cardiovascular risk may limit the cardioprotective effects of aspirin."
The study found that when patients took a single dose of ibuprofen beforehand, aspirin lost 98 percent of its blood-thinning power. If aspirin was taken first, three daily doses of ibuprofen eliminated 90 per cent of aspirin's benefit.
The study found show no conflict between aspirin and three other arthritis drugs: rofecoxib, diclofenac, and acetaminophen.