My neighbor and I bought 20 cases of water yesterday and we're going through our clothes, sheets, towels, etc. and will take them to the local Salvation Army. They are organizing now.
You can call them and see what they suggest. We all have to help.
The best thing you can donate is cash. It actually costs more money to handle clothes than it does a cash donation. Plus, then they can spend it on whatever is needed most, and they have the power to buy in bulk.