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Who Are We? Coming of Age on Antidepressants
NY Times ^ | April 15, 2008 | RICHARD A. FRIEDMAN, M.D.

Posted on 04/16/2008 11:06:29 PM PDT by neverdem

“I’ve grown up on medication,” my patient Julie told me recently. “I don’t have a sense of who I really am without it.”

At 31, she had been on one antidepressant or another nearly continuously since she was 14. There was little question that she had very serious depression and had survived several suicide attempts. In fact, she credited the medication with saving her life.

But now she was raising an equally fundamental question: how the drugs might have affected her psychological development and core identity.

It was not an issue I had seriously considered before. Most of my patients, who are adults, developed their psychiatric problems after they had a pretty clear idea of who they were as individuals. During treatment, most of them could tell me whether they were back to their normal baseline.

Julie could certainly remember what depression felt like, but she could not recall feeling well except during her long treatment with antidepressant medications. And since she had not grown up before getting depressed, she could not gauge the hypothetical effects of antidepressants on her emotional and psychological development.

Her experience is far from unique...

--snip--

The reason has to do with the way drugs are tested and approved. To get F.D.A. approval, a drug has to beat a placebo in two randomized clinical trials that typically involve a few hundred subjects who are treated for relatively short periods, usually 4 to 12 weeks...

--snip--

This large gap in our clinical knowledge is compounded by the public’s growing and well-founded skepticism about research sponsored by drug makers. A study in the January 2008 issue of The New England Journal of Medicine, involving 74 clinical trials with 12 antidepressants, found that 97 percent of positive studies were published, versus 12 percent of negative studies...

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society
KEYWORDS: antidepressants; depression; health; medicine; ssris
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To: Enduro Guy

Hang tough, and remember we’re here if you need us.


21 posted on 04/17/2008 6:40:03 AM PDT by Tijeras_Slim (Play that Funky Music Typical White Boy!)
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To: neverdem

Went to my MD for sleeping problem a few years ago. She prescribed Zoloft and I slept like I was dead but I gained 20 lbs in a month. Went off it. Went back this past year because I have googled my @ss off to find out what’s wrong with me. Thyroid/adrenals. She wanted to give me zoloft agin. Said no. She decided (with my prodding) to so a sonogram of my thyroid. Came back with multiple nodules. She wanted to wait to see what it will do and STILL wanted to give me antidepressants. I said no and to refer to an endocrinologist. He suspects Cushings and isn’t prescribing an EFing antidepressant.


22 posted on 04/17/2008 6:49:39 AM PDT by gopheraj
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To: neverdem

btt


23 posted on 04/17/2008 7:11:54 AM PDT by what's up
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To: utherdoul; Conservativegreatgrandma; Secret Agent Man; Enduro Guy; wally_bert; neverdem
I have one friend and one family member that I describe as “A Walking Walgreens” because they take SO many meds, mostly psycho stuff. They both take two different antidepressants and two anti anxiety meds. They are both miserable.

I've concluded from these two (they don't know each other) and from my own experience with migraines, that any neurological issue will eventually "learn" its way around any Rx that you throw at it. Eventually they don't work anymore, but any attempt to withdraw becomes a horrifying prospect.

Meanwhile, I have two teenagers (!). Depression in them manifests as anger, defiance, withdrawal, and low frustration tolorance. When they get like that, they get a glass of water and a little pill cup containing the following:

1000 mg. fish oil, enteric coated
1 B complex tablet, timed released, 50mg each
1 extra folic acid, 400 mcg. (around $.01 apiece!)
1 extra B1 (thiamine) 50-100mg each.

Works like a champ. They're fine within a few hours. Lasts a few days, unless I remember to chase them down with more before another "down" mood kicks in.

They used to protest, but it's worked so reliably that they now know that they'll feel better quickly, so they're quite willing.

24 posted on 04/17/2008 9:21:53 AM PDT by oprahstheantichrist (Stop calling them "liberals," they're Bolsheviks!)
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To: oprahstheantichrist

Thank you for the recipe, I just may give it a shot.


25 posted on 04/17/2008 9:24:59 AM PDT by wally_bert (Tactical Is Still Missing A Chair!)
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To: buccaneer81

“Here’s my advice to those considering SSRIs: Have another drink, go to a shrink, eat Ben & Jerry’s, smoke if you got’em. Anything but that psycho poison they try to prescribe.”

______________________________________________________________________________

As a former Celexa victim, I agree 100 percent with your post.

I still get those accursed “zaps” on occasion, and I’ve been off the drug for five years! (Only took it for 18 months...)


26 posted on 04/17/2008 9:28:45 AM PDT by Mugwump
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To: buccaneer81

I would never dismiss the benefit of SSRI’s out of hand.

Drugs work differently on different people. My daughter cannot take SSRI’s but she’s done really well on Wellbutrin.

I hope people won’t be frightened off of getting help because of these studies or because some people have had bad experiences.


27 posted on 04/17/2008 10:01:29 AM PDT by altura
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To: wally_bert
Welcome!

I forgot about vit. D, also. Usually I forget that one, but in higher doses D helps with depression also. Walmart now carries D in 2000 I.U. tablets.

Google that or any of the above with "depression," and you'll see amazing stuff, all double-blind, peer reviewed, etc.

28 posted on 04/17/2008 10:02:46 AM PDT by oprahstheantichrist (Stop calling them "liberals," they're Bolsheviks!)
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To: oprahstheantichrist

Good for you. A parent that really cares for your child. They put my mom on this crap and it’s taken more and more of it over the years just to get her to be somewhat comfortable. She’s on so many meds I don’t even know how many. It’s a mess and I resent the docs and their meds to the point I won’t go to a doc unless there’s absolutely no other way. I’m gonna die some day anyway.


29 posted on 04/17/2008 11:08:41 AM PDT by Conservativegreatgrandma
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To: oprahstheantichrist

Vitamin D is an amazing vitamin. I’ve ramped up mine and I haven’t had a cold since.


30 posted on 04/17/2008 11:10:20 AM PDT by Conservativegreatgrandma
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To: utherdoul

Holy mackeral! You sound like you could use some major prayer intervention, FRiend. I’m certain many FReepers would be willing to help. Your thoughts?


31 posted on 04/17/2008 11:14:01 AM PDT by getmeouttaPalmBeachCounty_FL (****************************Stop Continental Drift**)
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To: Enduro Guy; wally_bert
Do a search on SSRI withdrawal syndrome or SSRI discontinuation syndrome.

The preferred way to stop SSRI therapy is to switch to fluoxetine, i.e. generic Prozac, and gradually reduce the dose to zero. IIRC, someone wrote on this forum that it took that person months of tapering in order to do it with tolerable symptoms.

Fluoxetine has the longest half-life of the all the SSRI antidepressants. A fluoxetine taper will minimize withdrawal symptoms. Find a doc who knows this.

32 posted on 04/17/2008 12:00:53 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: neverdem

My best friend was diagnosed with bipolar disorder. They put him on some high powered pills, and he spent six months as a zombie.

One day he said “Enough!” and found a doctor who would help the problem, not treat the symptoms.

There are very few disorders where medication alone is the answer.


33 posted on 04/17/2008 3:36:13 PM PDT by redgolum ("God is dead" -- Nietzsche. "Nietzsche is dead" -- God.)
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To: neverdem
I took Zoloft for about six months, felt much better but then started taking it again about two years later, again for about six months.

It worked for me but I don't see how people can take the stuff for years on end.

The side effects were a problem.

Difficulty falling asleep.

Long, intense technicolor dreams every night. I would wake up exhausted.

It definitely helped my attitude during the day but it distorted my visual acuity in that every object had the most vivid, almost neon colors.

Then there was also a sexual side-effect as well.

I never felt addicted and simply had no desire get more after a few months of use.

These drugs are extremely powerful for adults and there's no way I would advise any parent to put their child on them unless it were a last resort.

34 posted on 04/17/2008 4:10:40 PM PDT by primeval patriot
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To: oprahstheantichrist

Beware of the folic acid. It could mask a B12 deficiency which is a lot more common than thought, especially with prevacid, etc. B12 deficiency can mimic depression, dementia, alzheimers, etc, because it plays a HUGE role in the nervous system.

I have a deficiency, discovered late. Someday when my #s get up to normal, I will start the process of quitting cymbalta and see what happens.


35 posted on 04/17/2008 4:51:30 PM PDT by Patriotic1 (Dic mihi solum facta, domina - Just the facts, ma'am)
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To: altura
I hope people won’t be frightened off of getting help because of these studies or because some people have had bad experiences.

The posters who hate the meds usually get here before the ones who appreciate them. For the case of this thread, Wellbutrin is evil as well.

36 posted on 04/17/2008 4:52:53 PM PDT by Patriotic1 (Dic mihi solum facta, domina - Just the facts, ma'am)
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To: primeval patriot
It worked for me but I don't see how people can take the stuff for years on end. The side effects were a problem.

Because not everyone gets the side effects, or if they do, it is minor.

37 posted on 04/17/2008 4:57:10 PM PDT by Patriotic1 (Dic mihi solum facta, domina - Just the facts, ma'am)
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To: oprahstheantichrist

Thanks for sharing what works with your children. I bet that might work for other people as well. Certainly they could try it without suffering any ill effects (unless allergies to fish or something!).


38 posted on 04/17/2008 5:26:31 PM PDT by Secret Agent Man (I'd like to tell you, but then I'd have to kill you.)
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To: Patriotic1

It’s not that everyone considers medicines evil. It isn’t as much a question of ‘evil’ as a question of ‘ONLY’. What we have a problem with is that they are regarded as being safer and better and always the superior form of treatment for anything anyone has. That mentality shuts a lot of potential doors for other healing possibilities, given the fact that 40-50% of people on a given drug, the drug won’t work for them.


39 posted on 04/17/2008 5:34:20 PM PDT by Secret Agent Man (I'd like to tell you, but then I'd have to kill you.)
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