Posted on 12/26/2008 11:06:39 PM PST by neverdem
Human parechovirus is a harmless virus which is encountered by most infants and displays few symptoms. Suspected of triggering type 1 diabetes in susceptible people, research methods need to take this "silent" virus into consideration. This comes from findings in a study from the Norwegian Institute of Public Health.
This study was part of a long-term project at the Norwegian Institute of Public Health to investigate if environmental risk factors affect type 1 diabetes. Faecal samples and questionnaires about the health of 102 children were sent in monthly by their parents for closer study.
Researchers wanted to see how common human parechovirus infections were among Norwegian infants. Existing research indicates that a related virus which only affects rodents, Ljungan virus, has been linked to the development of rodent diabetes.
Common virus
By studying stool samples from 102 infants and comparing feedback from parents about their child's health over three years, no significant link could be found between infection episodes and typical symptoms such as coughing, sneezing, vomiting, diarrhoea or fever. By the age of two, 86 percent of the infants had evidence of parechovirus in their faeces, and 94 percent by the age of three. Human parechovirus 1 was the most prevalent type (76 percent) followed by human parechoviruses 3 and 6 (13 percent and 9 percent respectively).
The researchers also noticed an increase in parechovirus infection between the ages of 6 and 18 months. This could be due to the loss of maternal antibodies by 6 months of age or the exposure to nursery/play groups that often begins at this age in Norway. Most infections occurred during September to December.
The 102 infants were recruited from babies born in 2004, with half from the high risk group for diabetes type 1 and the rest from a low risk group. The "high-risk" group included babies who had been identified at birth to carry the HLA genotype conferring the highest known risk for type 1 diabetes. The group not carrying the high-risk genotype included babies born at the same time and in the same area to the high risk babies.
The researchers conclude that most infants are infected by human parechovirus without displaying symptoms and so the total number of previous infections should be considered when looking for triggers for type 1 diabetes among those who are genetically at risk. Perhaps too few infections or infection at a too late time point could be important.
Source : Norwegian Institute of Public Health
If almost all the babies got the virus, then what difference does it make if it predisposes to Diabetes 1 or not. It is almost like saying: being born predisposes to Diabetes.
You may be able to vaccinate for the virus. You may be able to take precautions to prevent the child from getting the virus before a certain age. You may be able to study the virus to find out what it does that causes the diabetes and reverse the damage or find ways of blocking the damage from occuring.
If almost all babies get the virus, then on what basis can it be said that the virus triggers diabetes?
In order to be able to link the virus to the triggering of diabetes, it must be shown that all of the susceptible babies who develop diabetes have been exposed to the virus, and that none of the susceptible babies who have not been exposed to the virus develop diabetes.
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