The DEA treated California the same way over medical pot at first. It just depends on how serious the state government is about it. State and local police outnumber the feds a thousand to one; and I don’t see Washington sending in troops.
The Feds bribe the local lickspittle Vichy turncoats with a share of the loot.
Let’s ask the Romans how that plan usually turns out for the employers of mercenary thugs.