Posted on 09/29/2009 2:16:46 PM PDT by neverdem
Poor bone fracture healing could be next on the list of conditions linked to diabetes, U.S. researchers say.
The report, published in the American Journal of Pathology, suggests those with diabetes may have increased production of an inflammatory molecule known as TNF that causes bone fractures to heal more slowly and less satisfactorily.
Dr. Dana Graves and colleagues of the University of Medicine and Dentistry of New Jersey in Newark and the Boston University School of Medicine looked at bone repair in a mouse model of diabetes.
The researchers find increased levels of inflammatory molecules, particularly TNF-alpha and a mediator known as FOXO1. The researchers suggest these were linked to the rapid loss of cartilage in the area of the fractured bones.
The loss of cartilage, the researchers say, was due to increased numbers of osteoclasts -- cells that remove bone and cartilage.
"TNF-alpha dysregulation plays a prominent role in the recently identified catabolic events associated with diabetic fracture healing," the study authors say in a statement.
Diabetes: Incidence of childhood type 1 diabetes: a worrying trend
The second link is unrelated to bone fracture. It may require registration, not subscription.
As for researching it on Google, there's an avalanche of information, but hard for me to sort out what's really relevant, almost impossible for me to make a real assessmnt of risks vs benefits..
Anybody?
20 years ago my SIL broke her elbow and it was very slow to heal. The doc said it was because of diabetes.
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a603010.html
That’s the generic name for Humira.
Save the homepage for that website. It’s intended for the general public. It’s pretty comprehensive. Good luck!
FReepmail me if you want on or off the diabetes ping list.
In May during my Cancer surgery they broke 2 ribs.
Still healing . . .
As a side note, this week I start Insulin. Maybe I will heal faster.
Thanks. I’m looking into it now.
Obviously, diabetes slows all healing. - Just the reduction in blood circulation is enough to slow the process.
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